2zaz
From Proteopedia
(New page: 200px<br /><applet load="2zaz" size="350" color="white" frame="true" align="right" spinBox="true" caption="2zaz, resolution 1.800Å" /> '''Crystal structure o...) |
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==Overview== | ==Overview== | ||
| - | The biphenyl amides (BPAs) are a novel series of p38 MAP kinase | + | The biphenyl amides (BPAs) are a novel series of p38 MAP kinase inhibitors. The discovery of the series through structure-based focused screening is described, and the binding mode of the compounds is explained with reference to X-ray crystal structures. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Mitogen-activated protein kinase]] | [[Category: Mitogen-activated protein kinase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Somers, D | + | [[Category: Somers, D O.]] |
[[Category: ACT]] | [[Category: ACT]] | ||
[[Category: GK1]] | [[Category: GK1]] | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:01:10 2008'' |
Revision as of 17:01, 21 February 2008
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Crystal structure of P38 in complex with 4-anilino quinoline inhibitor
Overview
The biphenyl amides (BPAs) are a novel series of p38 MAP kinase inhibitors. The discovery of the series through structure-based focused screening is described, and the binding mode of the compounds is explained with reference to X-ray crystal structures.
About this Structure
2ZAZ is a Single protein structure of sequence from Homo sapiens with , and as ligands. Active as Mitogen-activated protein kinase, with EC number 2.7.11.24 Full crystallographic information is available from OCA.
Reference
Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode., Angell RM, Bamborough P, Cleasby A, Cockerill SG, Jones KL, Mooney CJ, Somers DO, Walker AL, Bioorg Med Chem Lett. 2008 Jan 1;18(1):318-23. Epub 2007 Nov 19. PMID:18006306
Page seeded by OCA on Thu Feb 21 19:01:10 2008
