2bwq
From Proteopedia
| Line 25: | Line 25: | ||
[[Category: transport protein]] | [[Category: transport protein]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 16:50:23 2007'' |
Revision as of 14:45, 30 October 2007
|
CRYSTAL STRUCTURE OF THE RIM2 C2A-DOMAIN AT 1.4 ANGSTROM RESOLUTION
Overview
RIMs are large proteins that contain two C2-domains and are localized at, presynaptic active zones, where neurotransmitters are released. RIMs play, key roles in synaptic vesicle priming and regulation of presynaptic, plasticity. A mutation in the RIM1 C2A-domain has been implicated in, autosomal dominant cone-rod dystrophy (CORD7). The RIM C2A-domain does not, contain the full complement of aspartate residues that commonly mediate, Ca2+ binding at the top loops of C2-domains, and has been reported to, interact with SNAP-25 and synaptotagmin 1, two proteins from the, Ca2+-dependent membrane fusion machinery. Here we have used NMR, spectroscopy and X-ray crystallography to analyze the structure and, biochemical properties of the RIM2 C2A-domain, which is closely related to, the RIM1 ... [(full description)]
About this Structure
2BWQ is a [Single protein] structure of sequence from [Rattus norvegicus] with SO4 as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Crystal structure of the RIM2 C2A-domain at 1.4 A resolution., Dai H, Tomchick DR, Garcia J, Sudhof TC, Machius M, Rizo J, Biochemistry. 2005 Oct 18;44(41):13533-42. PMID:16216076
Page seeded by OCA on Tue Oct 30 16:50:23 2007
