2rf2
From Proteopedia
(New page: 200px<br /><applet load="2rf2" size="350" color="white" frame="true" align="right" spinBox="true" caption="2rf2, resolution 2.4Å" /> '''HIV reverse transcrip...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2RF2 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=MRX:'>MRX</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RF2 OCA]. | + | 2RF2 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=MRX:'>MRX</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] Known structural/functional Site: <scene name='pdbsite=AC1:Mrx+Binding+Site+For+Residue+A+561'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RF2 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: zinc-finger]] | [[Category: zinc-finger]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 13 08:18:35 2008'' |
Revision as of 06:18, 13 February 2008
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HIV reverse transcriptase in complex with inhibitor 7e (NNRTI)
Overview
This Letter describes the design, synthesis, and biological evaluation of, novel 3-indole sulfonamides as potent non-nucleoside reverse transcriptase, inhibitors (NNRTIs) with balanced profiles against common HIV RT mutants, K103N and Y181C.
About this Structure
2RF2 is a Protein complex structure of sequences from Human immunodeficiency virus 1 with as ligand. Active as RNA-directed DNA polymerase, with EC number 2.7.7.49 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Novel indole-3-sulfonamides as potent HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs)., Zhao Z, Wolkenberg SE, Lu M, Munshi V, Moyer G, Feng M, Carella AV, Ecto LT, Gabryelski LJ, Lai MT, Prasad SG, Yan Y, McGaughey GB, Miller MD, Lindsley CW, Hartman GD, Vacca JP, Williams TM, Bioorg Med Chem Lett. 2007 Nov 28;. PMID:18083561
Page seeded by OCA on Wed Feb 13 08:18:35 2008
Categories: Human immunodeficiency virus 1 | Protein complex | RNA-directed DNA polymerase | Prasad, S. | Yan, Y. | MRX | Aids | Ais | Aspartyl protease | Capsid maturation | Core protein | Cytoplasm | Dna integration | Dna recombination | Dna-directed dna polymerase | Endonuclease | Hiv-1 revers transcriptase | Host-virus interaction | Hydrolase | Lipoprotein | Magnesium | Membrane | Metal-binding | Multifunctional enzyme | Myristate | Non-nucleoside inhibition | Nuclease | Nucleotidyltransferase | Nucleus | Phosphorylation | Protease | Rna-binding | Rna-directed dna polymerase | Viral nucleoprotein | Virion | Zinc | Zinc-finger
