Phosphoinositide 3-Kinases

<scene name='User:David_Canner/Sandbox_P/Nsh2_disruption_of_salt/1'>Glu 542 and nSH2 is disrupted upon binding phosphorylated peptides</scene>

<scene name='User:David_Canner/Sandbox_P/Nsh2_disruption_of_salt/1'>Glu 542 and nSH2 is disrupted upon binding phosphorylated peptides</scene>

{{STRUCTURE_3hhm| right| PDB=3hhm | SCENE=User:David_Canner/Sandbox_P/Opening/1 |CAPTION= PI3K p110α Subunit, [[3hhm]] }}

{{STRUCTURE_3hhm| right| PDB=3hhm | SCENE=User:David_Canner/Sandbox_P/Opening/1 |CAPTION= PI3K p110α Subunit, [[3hhm]] }}

<scene name='User:David_Canner/Sandbox_P/Wortmannin/2'>Wortmannin</scene>

<scene name='User:David_Canner/Sandbox_P/Wortmannin/2'>Wortmannin</scene>

<scene name='User:David_Canner/Sandbox_P/Wortmannnin_binding_for_reals/1'>forms a covalent bond with Lys 802 and hydrogen bonds with Asp 933, Tyr 836, Val 851 and Gln 859</scene>

<scene name='User:David_Canner/Sandbox_P/Wortmannnin_binding_for_reals/1'>forms a covalent bond with Lys 802 and hydrogen bonds with Asp 933, Tyr 836, Val 851 and Gln 859</scene>