Sandbox 35
From Proteopedia
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| - | Lysozyme is an enzyme that breaks down cell walls by hydrolyzing certain glycosidic linkages in the peptidoglycan of cell walls. | + | Lysozyme is an enzyme that breaks down cell walls by hydrolyzing certain glycosidic linkages in the peptidoglycan of cell walls. It is found in the cells and secretions of various vertebrates, and likely functions as an bacteria-killing or -disposal agent. The lysozyme found in hen egg white has been investigated more thoroughly than other species of lysozyme, and so is better understood then most enzymes.<ref>Voet, D., Voet, J., Pratt, C.(2008) Fundamentals of Biochemistry: Life at the Molecular Level, 3rd edition. John Wiley and Sons, Inc.</ref> |
== History == | == History == | ||
| - | HEW Lysozyme was the first enzyme to have its structure determined in 1965 by David Phillips. Phillips initially elucidated the structure through X-Ray crystallography and then continued his investigation of substrate binding by building models of the enzyme. | + | HEW Lysozyme was the first enzyme to have its structure determined in 1965 by David Phillips. Phillips initially elucidated the structure through X-Ray crystallography and then continued his investigation of substrate binding by building models of the enzyme. The PDB code of HEW lysozyme is 3IJU and the assigned EC number for lysozyme is EC 3.2.1.17. |
== Structure == | == Structure == | ||
=== Basics === | === Basics === | ||
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| + | HEW Lysozyme is a small enzyme, weighing only 14.3 kD and consisting of only 129 amino acid residues. | ||
<applet load='3IJU' size='400' frame='true' align='right' caption='Basic Structure of HEW Lysozyme.' /> | <applet load='3IJU' size='400' frame='true' align='right' caption='Basic Structure of HEW Lysozyme.' /> | ||
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== Current Uses == | == Current Uses == | ||
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| + | ==References== | ||
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| + | <references/> | ||
Revision as of 01:19, 30 October 2010
| Please do NOT make changes to this Sandbox. Sandboxes 30-60 are reserved for use by Biochemistry 410 & 412 at Messiah College taught by Dr. Hannah Tims during Fall 2012 and Spring 2013. |
Contents |
Lysozyme - Hen Egg White (HEW)
Lysozyme is an enzyme that breaks down cell walls by hydrolyzing certain glycosidic linkages in the peptidoglycan of cell walls. It is found in the cells and secretions of various vertebrates, and likely functions as an bacteria-killing or -disposal agent. The lysozyme found in hen egg white has been investigated more thoroughly than other species of lysozyme, and so is better understood then most enzymes.[1]
History
HEW Lysozyme was the first enzyme to have its structure determined in 1965 by David Phillips. Phillips initially elucidated the structure through X-Ray crystallography and then continued his investigation of substrate binding by building models of the enzyme. The PDB code of HEW lysozyme is 3IJU and the assigned EC number for lysozyme is EC 3.2.1.17.
Structure
Basics
HEW Lysozyme is a small enzyme, weighing only 14.3 kD and consisting of only 129 amino acid residues.
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Secondary Sructures
Ligands and Intermolecular Forces
Catalytic Reaction
Mechanism
Current Uses
References
- ↑ Voet, D., Voet, J., Pratt, C.(2008) Fundamentals of Biochemistry: Life at the Molecular Level, 3rd edition. John Wiley and Sons, Inc.
