Sandbox 35
From Proteopedia
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=== Ligands and Intermolecular Forces === | === Ligands and Intermolecular Forces === | ||
Revision as of 01:51, 30 October 2010
| Please do NOT make changes to this Sandbox. Sandboxes 30-60 are reserved for use by Biochemistry 410 & 412 at Messiah College taught by Dr. Hannah Tims during Fall 2012 and Spring 2013. |
Contents |
Lysozyme - Hen Egg White (HEW)
Lysozyme is an enzyme that breaks down cell walls by hydrolyzing certain glycosidic linkages in the peptidoglycan of cell walls. It is found in the cells and secretions of various vertebrates, and likely functions as an bacteria-killing or -disposal agent. The lysozyme found in hen egg white has been investigated more thoroughly than other species of lysozyme, and so is better understood then most enzymes.[1] The PDB code of HEW lysozyme shown on this page is 3IJU and the assigned EC number for lysozyme is EC 3.2.1.17.
History
The enzyme Lysozoyme was first discovered in 1922 by Alexander Fleming. Fleming
The structure of HEW Lysozyme was investigated and found in 1965 by David Phillips, making it the first enzyme to have its structure determined. Phillips initially elucidated the structure through X-Ray crystallography and then continued his investigation of substrate binding by building models of the enzyme.[2]
Structure
Basics
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HEW Lysozyme is a small enzyme, weighing only 14.3 kD and consisting of only 129 amino acid residues.
Secondary Sructures
