Sandbox 33
From Proteopedia
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Hen Egg-White Lysozyme | Hen Egg-White Lysozyme | ||
| - | <applet load='1hew' size='400' frame='true' align='right' caption=' This Jmol image allows us to see the general folding pattern of Hen Egg-White Lysozyme (PDBid:1hew).' | ||
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Hen Egg-White Lysozyme is an enzyme that was first described by the Russian scientist P. Laschtchenko in 1909 and its structure was solved for in 1965 by David Phillips via X-ray crystallography (Garrett, & Grisham, 2005). It is a single polymer of 129 residues (14.3kDa in weight) that catalyzes the hydrolysis of the polysaccharide wall of bacterial cells, breaking the β (1-4) linkage between N-acetylmuramic acid (NAM) and N-acetylglucosamine between the D and E sugars. The D and E sugars are the fourth and fifth sugars, respectively, in reference to the six sugars (oligosaccharide), identified by the letters A-F, that function as the ligand and bind to lysozyme. In hens (Gallus gallus), lysozyme is heavily concentrated in the egg white, serving as an anti-biotic as well as a nutrient to the developing eggs <ref>http://www.ncbi.nlm.nih.gov/pubmed/1569548?dopt</ref>. | Hen Egg-White Lysozyme is an enzyme that was first described by the Russian scientist P. Laschtchenko in 1909 and its structure was solved for in 1965 by David Phillips via X-ray crystallography (Garrett, & Grisham, 2005). It is a single polymer of 129 residues (14.3kDa in weight) that catalyzes the hydrolysis of the polysaccharide wall of bacterial cells, breaking the β (1-4) linkage between N-acetylmuramic acid (NAM) and N-acetylglucosamine between the D and E sugars. The D and E sugars are the fourth and fifth sugars, respectively, in reference to the six sugars (oligosaccharide), identified by the letters A-F, that function as the ligand and bind to lysozyme. In hens (Gallus gallus), lysozyme is heavily concentrated in the egg white, serving as an anti-biotic as well as a nutrient to the developing eggs <ref>http://www.ncbi.nlm.nih.gov/pubmed/1569548?dopt</ref>. | ||
Lysozyme is not only found in hen egg-whites but has many homologs that occur in a wide variety of organisms including humans. The gene for lysozyme in hens is expressed in the oviduct and in macrophages, which directly reflects its purposes (i.e. nutrition and defense). The one gene is controlled at the level of transcription by different means for the different locations and resulting functions (Worthington, 2010). | Lysozyme is not only found in hen egg-whites but has many homologs that occur in a wide variety of organisms including humans. The gene for lysozyme in hens is expressed in the oviduct and in macrophages, which directly reflects its purposes (i.e. nutrition and defense). The one gene is controlled at the level of transcription by different means for the different locations and resulting functions (Worthington, 2010). | ||
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| + | <applet load='1hew' size='400' frame='true' align='right' caption=' This Jmol image allows us to see the general folding pattern of Hen Egg-White Lysozyme (PDBid:1hew).' scene='Sandbox_33/First_look/1'> | ||
=Structure= | =Structure= | ||
Revision as of 15:48, 30 October 2010
| Please do NOT make changes to this Sandbox. Sandboxes 30-60 are reserved for use by Biochemistry 410 & 412 at Messiah College taught by Dr. Hannah Tims during Fall 2012 and Spring 2013. |
Hen Egg-White Lysozyme
Background
Hen Egg-White Lysozyme is an enzyme that was first described by the Russian scientist P. Laschtchenko in 1909 and its structure was solved for in 1965 by David Phillips via X-ray crystallography (Garrett, & Grisham, 2005). It is a single polymer of 129 residues (14.3kDa in weight) that catalyzes the hydrolysis of the polysaccharide wall of bacterial cells, breaking the β (1-4) linkage between N-acetylmuramic acid (NAM) and N-acetylglucosamine between the D and E sugars. The D and E sugars are the fourth and fifth sugars, respectively, in reference to the six sugars (oligosaccharide), identified by the letters A-F, that function as the ligand and bind to lysozyme. In hens (Gallus gallus), lysozyme is heavily concentrated in the egg white, serving as an anti-biotic as well as a nutrient to the developing eggs [1]. Lysozyme is not only found in hen egg-whites but has many homologs that occur in a wide variety of organisms including humans. The gene for lysozyme in hens is expressed in the oviduct and in macrophages, which directly reflects its purposes (i.e. nutrition and defense). The one gene is controlled at the level of transcription by different means for the different locations and resulting functions (Worthington, 2010).
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