3p1a
From Proteopedia
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{{STRUCTURE_3p1a| PDB=3p1a | SCENE= }} | {{STRUCTURE_3p1a| PDB=3p1a | SCENE= }} | ||
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===Structure of human Membrane-associated Tyrosine- and Threonine-specific cdc2-inhibitory kinase MYT1 (PKMYT1)=== | ===Structure of human Membrane-associated Tyrosine- and Threonine-specific cdc2-inhibitory kinase MYT1 (PKMYT1)=== | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/PMYT1_HUMAN PMYT1_HUMAN]] Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.<ref>PMID:9001210</ref> <ref>PMID:10373560</ref> | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[3p1a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P1A OCA]. | |
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| + | ==Reference== | ||
| + | <references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
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[[Category: Transferase]] | [[Category: Transferase]] | ||
[[Category: Tyrosine- and threonine-specific kinase]] | [[Category: Tyrosine- and threonine-specific kinase]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 3 11:14:36 2010'' | ||
Revision as of 08:14, 2 May 2013
Contents |
Structure of human Membrane-associated Tyrosine- and Threonine-specific cdc2-inhibitory kinase MYT1 (PKMYT1)
Function
[PMYT1_HUMAN] Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.[1] [2]
About this Structure
3p1a is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- ↑ Liu F, Stanton JJ, Wu Z, Piwnica-Worms H. The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex. Mol Cell Biol. 1997 Feb;17(2):571-83. PMID:9001210
- ↑ Liu F, Rothblum-Oviatt C, Ryan CE, Piwnica-Worms H. Overproduction of human Myt1 kinase induces a G2 cell cycle delay by interfering with the intracellular trafficking of Cdc2-cyclin B1 complexes. Mol Cell Biol. 1999 Jul;19(7):5113-23. PMID:10373560
Categories: Homo sapiens | Non-specific serine/threonine protein kinase | Arrowsmith, C H. | Berridge, G. | Bountra, C. | Chaikuad, A. | Cooper, C D.O. | Delft, F von. | Edwards, A M. | Eswaran, J. | Fedorov, O. | Knapp, S. | Kroeler, T. | Krojer, T. | Muniz, J R.C. | Pike, A C.W. | SGC, Structural Genomics Consortium. | Vollmar, M. | Weigelt, J. | Membrane-associated protein kinase | Protein kinase | Sgc | Structural genomic | Structural genomics consortium | Transferase | Tyrosine- and threonine-specific kinase
