AZT-resistant HIV-1 reverse transcriptase
From Proteopedia
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==Role of Reverse Transcriptase in HIV Replication== | ==Role of Reverse Transcriptase in HIV Replication== | ||
| - | Reverse Transcriptase (RT) allows HIV to create DNA from its RNA. | + | Reverse Transcriptase (RT) allows HIV to create DNA from its RNA. RT has two enzymatic activities: DNA polymerase and RNase H. DNA polymerase is necessary for copying a DNA or RNA template, while RNase H cleaves the RNA that is part of the DNA/RNA duplex. These two activities combine to convert RNA into linear, double-stranded DNA. This DNA is then incorporated in the host's genome. |
Revision as of 02:49, 4 November 2010
Role of Reverse Transcriptase in HIV Replication
Reverse Transcriptase (RT) allows HIV to create DNA from its RNA. RT has two enzymatic activities: DNA polymerase and RNase H. DNA polymerase is necessary for copying a DNA or RNA template, while RNase H cleaves the RNA that is part of the DNA/RNA duplex. These two activities combine to convert RNA into linear, double-stranded DNA. This DNA is then incorporated in the host's genome.
AZT Resistance
Proteopedia Page Contributors and Editors (what is this?)
Alexandra Clement, David Canner, Michal Harel, Alexander Berchansky
