2pqw
From Proteopedia
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==Overview== | ==Overview== | ||
| - | Crystal structures of the L3MBTL1 MBT repeats in complex with histone H4 | + | Crystal structures of the L3MBTL1 MBT repeats in complex with histone H4 peptides dimethylated on Lys20 (H4K20me2) show that only the second of the three MBT repeats can bind mono- and dimethylated histone peptides. Its binding pocket has similarities to that of 53BP1 and is able to recognize the degree of histone lysine methylation. An unexpected mode of peptide-mediated dimerization suggests a possible mechanism for chromatin compaction by L3MBTL1. |
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | L3MBTL1 recognition of mono- and dimethylated histones., Min J, Allali-Hassani A, Nady N, Qi C, Ouyang H, Liu Y, | + | L3MBTL1 recognition of mono- and dimethylated histones., Min J, Allali-Hassani A, Nady N, Qi C, Ouyang H, Liu Y, MacKenzie F, Vedadi M, Arrowsmith CH, Nat Struct Mol Biol. 2007 Dec;14(12):1229-30. Epub 2007 Nov 18. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18026117 18026117] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Allali-Hassani, A.]] | [[Category: Allali-Hassani, A.]] | ||
| - | [[Category: Arrowsmith, C | + | [[Category: Arrowsmith, C H.]] |
[[Category: Bochkarev, A.]] | [[Category: Bochkarev, A.]] | ||
[[Category: Crombet, L.]] | [[Category: Crombet, L.]] | ||
| - | [[Category: Edwards, A | + | [[Category: Edwards, A M.]] |
[[Category: Herzanych, N.]] | [[Category: Herzanych, N.]] | ||
[[Category: Kozieradzki, I.]] | [[Category: Kozieradzki, I.]] | ||
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[[Category: Loppnau, P.]] | [[Category: Loppnau, P.]] | ||
[[Category: Mackenzie, F.]] | [[Category: Mackenzie, F.]] | ||
| - | [[Category: Min, J | + | [[Category: Min, J R.]] |
[[Category: Ouyang, H.]] | [[Category: Ouyang, H.]] | ||
| - | [[Category: SGC, Structural | + | [[Category: SGC, Structural Genomics Consortium.]] |
[[Category: Sundstrom, M.]] | [[Category: Sundstrom, M.]] | ||
[[Category: Vedadi, M.]] | [[Category: Vedadi, M.]] | ||
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[[Category: transcription]] | [[Category: transcription]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:32:09 2008'' |
Revision as of 16:32, 21 February 2008
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Crystal structure of L3MBTL1 in complex with H4K20Me2 (residues 17-25), trigonal form
Overview
Crystal structures of the L3MBTL1 MBT repeats in complex with histone H4 peptides dimethylated on Lys20 (H4K20me2) show that only the second of the three MBT repeats can bind mono- and dimethylated histone peptides. Its binding pocket has similarities to that of 53BP1 and is able to recognize the degree of histone lysine methylation. An unexpected mode of peptide-mediated dimerization suggests a possible mechanism for chromatin compaction by L3MBTL1.
About this Structure
2PQW is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
L3MBTL1 recognition of mono- and dimethylated histones., Min J, Allali-Hassani A, Nady N, Qi C, Ouyang H, Liu Y, MacKenzie F, Vedadi M, Arrowsmith CH, Nat Struct Mol Biol. 2007 Dec;14(12):1229-30. Epub 2007 Nov 18. PMID:18026117
Page seeded by OCA on Thu Feb 21 18:32:09 2008
Categories: Homo sapiens | Single protein | Allali-Hassani, A. | Arrowsmith, C H. | Bochkarev, A. | Crombet, L. | Edwards, A M. | Herzanych, N. | Kozieradzki, I. | Liu, Y. | Loppnau, P. | Mackenzie, F. | Min, J R. | Ouyang, H. | SGC, Structural Genomics Consortium. | Sundstrom, M. | Vedadi, M. | Weigelt, J. | ACT | L(3)mbt-like protein | Sgc | Structural genomics | Structural genomics consortium | Transcription
