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Ribosomal protein L2

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(New page: Crystal Structure of Ribosomal protein L2 from ''Thermus thermophilus'' (2xg0, chain D) {{STRUCTURE_2xg0| PDB=2xg0 | SIZE=300| SCENE= |right|CAPTI...)
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[[Image:RPL2.png|left|200px|thumb|Crystal Structure of Ribosomal protein L2 from ''Thermus thermophilus'' ([[2xg0]], chain D)]]
[[Image:RPL2.png|left|200px|thumb|Crystal Structure of Ribosomal protein L2 from ''Thermus thermophilus'' ([[2xg0]], chain D)]]
{{STRUCTURE_2xg0| PDB=2xg0 | SIZE=300| SCENE= |right|CAPTION=Ribosomal protein L2 from ''Thermus thermophilus'' [[2xg0]], chain D }}
{{STRUCTURE_2xg0| PDB=2xg0 | SIZE=300| SCENE= |right|CAPTION=Ribosomal protein L2 from ''Thermus thermophilus'' [[2xg0]], chain D }}
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Ribosomal protein L2 (RPL2) is one of the 34 proteins which belong to the large 50S subunit of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. It is required for the association of the 30S and 50S subunits and is involved in the binding of tRNA at the A- and P-sites. In the archaea like in ''Haloarcula marismortui'', the L2 is called L2P (RPL2P). The images at the left and at the right correspond to one representative RPL2, ''i.e.'' the crystal structure of Ribosomal protein L2 from ''Thermus thermophilus'' ([[2xg0]], chain D).
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== 3D Structures of Ribosomal protein L2 ==
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=== RPL2 ===
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[[1rl2]] – RPL2 – Geobacillus stearothermophilus
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=== L2 in 50S subunit+RNA ===
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[[2xg0]], [[2xg2]], [[3kir]], [[3kit]], [[3kiw]], [[3kiy]] – TtRPL2 in 50S subunit+RNA fragments – Thermus thermophilus
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[[2x9s]], [[2x9u]], [[3kni]], [[3knk]], [[3knm]], [[3kno]], [[2wrj]], [[2wrl]], [[2wro]], [[2wrr]], [[3hux]], [[3huz]], [[2wh2]], [[2wh4]], [[2wdi]], [[2wdj]], [[2wdl]], [[2wdn]], [[1vsp]], [[2v47]], [[2v49]], [[1vsa]], [[2hgj]], [[2hgq]], [[2hgu]], [[2j01]], [[2j03]], [[1yl3]], [[3mrz]], [[3ms1]], [[3i8f]], [[3i8i]], [[3i9c]], [[3i9e]], [[3f1f]], [[3f1h]], [[3d5b]], [[3d5d]], [[2b66]], [[2b9n]], [[2b9p]], [[1giy]] - TtRPL2 in 50S subunit+5S RRNA+23S RRNA
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[[3fin]] - TtRPL2 in 50S subunit+5S RRNA+23S RRNA – Cryo-EM
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[[2wwq]] – EcRPL2 in 50S subunit+5S RRNA+23S RRNA+mRNA+P-site tRNA – Escherichia coli
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[[3i1n]], [[3i1p]], [[3i1r]], [[3i1t]], [[3i20]], [[3i22]], [[3e1b]], [[3e1d]], [[3df2]], [[3df4]], [[2vhn]], [[2qov]], [[2qox]], [[2i2t]], [[2i2v]], [[1vs6]], [[1vs8]], [[2aw4]], [[2awb]], [[3ofd]], [[3og0]] - EcRPL2 in 50S subunit+5S RRNA+23S RRNA
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[[3fik]], [[2gya]], [[2gyc]], [[3bbx]], [[1p85]], [[1p86]] - EcRPL2 in 50S subunit+5S RRNA+23S RRNA – Cryo-EM
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[[3kcr]] - EcRPL2 in 50S subunit+5S RRNA+23S RRNA+preprotein translocase
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[[2rdo]] - EcRPL2 in 50S subunit+5S RRNA+23S RRNA+EF-G+RRF – Cryo-EM
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[[3bbo]] - RPL2 in 50S subunit+5S RRNA+23S RRNA+4.8S RRNA – Cryo-EM – spinach
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[[3iy9]] – RPL2 in 50S subunit – Leishmania taretolae
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[[2zjq]], [[2zjr]] - DrRPL2 in 50S subunit+5S RRNA+23S RRNA – Deinococcus radiodurans
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[[1kqs]], [[1qvg]] - HmRPL2P in 50S subunit+5S RRNA+23S RRNA+CCA - Haloarcula marismortui
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[[1jj2]], [[1ffk]], [[3cc2]], [[2qa4]], [[1s72]] - HmRPL2P in 50S subunit+5S RRNA+23S RRNA
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[[3cc7]], [[3cce]], [[3ccj]], [[3ccl]], [[3ccm]], [[3ccq]], [[3ccr]], [[3ccs]], [[3ccu]], [[3ccv]] - HmRPL2P in 50S subunit+5S RRNA+23S RRNA (mutant)
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[[1vq4]], [[1vq5]], [[1vq7]], [[1vql]], [[1vqm]], [[1vqp]] - HmRPL2P in 50S subunit+5S RRNA+23S RRNA+transition state analog
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[[1vq6]], [[1vqk]], [[1vqn]] - HmRPL2P in 50S subunit+5S RRNA+23S RRNA+ c-hpmn+CCA-Phe-caproic acid-biotin
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[[1vqo]] - HmRPL2P in 50S subunit+5S RRNA+23S RRNA+ CCPMN
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[[1yhq]], [[1yi2]], [[1yij]], [[1yjn]], [[1yjw]] - HmRPL2P in 50S subunit+5S RRNA+23S RRNA (mutant)+antibiotic
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[[1yj9]] - HmRPL2P in 50S subunit (L22 mutant)+5S RRNA+23S RRNA
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[[1qvf]] - HmRPL2P in 50S subunit+5S RRNA+23S RRNA + deacylated tRNA minihelix
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[[1q86]] - HmRPL2P in 50S subunit+5S RRNA+23S RRNA+CCA-Phe-caproic acid-biotin
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=== L2 in 50S subunit + antibiotics ===
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[[3cxc]] – RPL2 in 50S subunit+5S RRNA+23S RRNA+oxazolidinone inhibitor – Halobacterium marismortui
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[[3dll]] - DrRPL2 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+oxazolidinone inhibitor
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[[2zjp]] - DrRPL2 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+nosiheptide
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[[3cf5]] - DrRPL2 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+thiostrepton
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[[1xbp]] - DrRPL2 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+thiamulin
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[[1sm1]] - DrRPL2 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+quinupristin+dalfopristin
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[[1nwx]] - DrRPL2 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+ABT-773
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[[1nwy]] - DrRPL2 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+azithromycin
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[[3oh5]], [[3oh7]] - TtRPL2 in 50S subunit+5S RRNA+23S RRNA+chloramphenicol
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[[3ohj]], [[3ohk]] - TtRPL2 in 50S subunit+5S RRNA+23S RRNA+erythromycin
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[[3ohz]], [[3oi1]] - TtRPL2 in 50S subunit+5S RRNA+23S RRNA+azithromycin
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[[3oi3]], [[3oi5]] - TtRPL2 in 50S subunit+5S RRNA+23S RRNA+telithromycin
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[[2qam]], [[2qao]], [[2qoz]], [[2qp1]] - EcRPL2 in 50S subunit+5S RRNA+23S RRNA+neomycin
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[[2qba]], [[2qbc]] - EcRPL2 in 50S subunit+5S RRNA+23S RRNA+gentamicin
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[[3ofc]] - EcRPL2 in 50S subunit+5S RRNA+23S RRNA+chloramphenicol
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[[3ofz]] - EcRPL2 in 50S subunit+5S RRNA+23S RRNA+clindamycin
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[[3ofq]], [[3ofr]] - EcRPL2 in 50S subunit+5S RRNA+23S RRNA+erythromycin
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[[1vt2]], [[3orb]] - EcRPL2 in 50S subunit+5S RRNA+23S RRNA+CEM-101
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[[1k73]], 1kc8, 1k8a, 1k9m, 1kd1, 1m1k, 3i55, 3i56, 3g4s, 3g6e, 3g71, 2qex, 3cpw, 3cc4, 3cd6, 2otj, 2otl, 1yit, 1q7y, 1q81, 1q82, 1n8r, 1nji - HmRPL2P in 50S subunit+5S RRNA+23S RRNA+antibiotics
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1m90, 3cma, 3cme, 1vq8, 1vq9 - HmRPL2P in 50S subunit+5S RRNA+23S RRNA+ sparsomycin+CCA-Phe-caproic acid-biotin
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=== L2 in 60S subunit ===
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3jyw - RPL2 in 60S subunit – Thermomyces lanuginosus – Cryo-EM
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2ftc - RPL2 in 60S subunit+16S RRNA - bovine
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1s1i - yRPL2 in 40S ribosomal subunit+18S RRNA+elongation factor 2 – Cryo-EM – yeast
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=== L2 in part of the large ribosomal subunit ===
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487d – RPL2+RPL1+RPL6+RPL9+RPL11+RPL14+RPL25 - Cryo-EM
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1c04 – HmRPL2P+RPL6+RPL11+RPS14+23S RRNA fragment
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=== L2 in large + small ribosomal subunit ===
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1ml5 - EcRPL2 in 50S ribosomal subunit+30S ribosomal subunit+THX+chain release factor 2+P-site tRNA+tRNA Phe+mRNA fragment+23S RRNA+5S RRNA+16S RRNA – EM
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=== L2 in 50S subunit + ribosome releasing factor (RRF) ===
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2qbe, 2qbg, 2qbi, 2qbk, 2z4l, 2z4n - EcRPL2 in 50S subunit+5S RRNA+23S RRNA+RRF
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=== L2 in 50S subunit + various proteins ===
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2vhm - EcRPL2 in 50S subunit+5S RRNA+23S RRNA+PDF C-terminal helix
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2j28 - EcRPL2 in 50S subunit+5S RRNA+23S RRNA+signal recognition particle – Cryo-EM
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1vor, 1vou, 1vow, 1voy, 1vp0, 1pnu, 1pny - EcRPL2 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc
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1nkw - DrRPL2 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc
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1w2b - HmRPL2P in 50S subunit+5S RRNA+23S RRNA+trigger factor N-terminal

Revision as of 10:44, 11 November 2010

Image:RPL2.png
Crystal Structure of Ribosomal protein L2 from Thermus thermophilus (2xg0, chain D)

Template:STRUCTURE 2xg0

Ribosomal protein L2 (RPL2) is one of the 34 proteins which belong to the large 50S subunit of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. It is required for the association of the 30S and 50S subunits and is involved in the binding of tRNA at the A- and P-sites. In the archaea like in Haloarcula marismortui, the L2 is called L2P (RPL2P). The images at the left and at the right correspond to one representative RPL2, i.e. the crystal structure of Ribosomal protein L2 from Thermus thermophilus (2xg0, chain D).

Contents

3D Structures of Ribosomal protein L2

RPL2

1rl2 – RPL2 – Geobacillus stearothermophilus


L2 in 50S subunit+RNA

2xg0, 2xg2, 3kir, 3kit, 3kiw, 3kiy – TtRPL2 in 50S subunit+RNA fragments – Thermus thermophilus 2x9s, 2x9u, 3kni, 3knk, 3knm, 3kno, 2wrj, 2wrl, 2wro, 2wrr, 3hux, 3huz, 2wh2, 2wh4, 2wdi, 2wdj, 2wdl, 2wdn, 1vsp, 2v47, 2v49, 1vsa, 2hgj, 2hgq, 2hgu, 2j01, 2j03, 1yl3, 3mrz, 3ms1, 3i8f, 3i8i, 3i9c, 3i9e, 3f1f, 3f1h, 3d5b, 3d5d, 2b66, 2b9n, 2b9p, 1giy - TtRPL2 in 50S subunit+5S RRNA+23S RRNA 3fin - TtRPL2 in 50S subunit+5S RRNA+23S RRNA – Cryo-EM 2wwq – EcRPL2 in 50S subunit+5S RRNA+23S RRNA+mRNA+P-site tRNA – Escherichia coli 3i1n, 3i1p, 3i1r, 3i1t, 3i20, 3i22, 3e1b, 3e1d, 3df2, 3df4, 2vhn, 2qov, 2qox, 2i2t, 2i2v, 1vs6, 1vs8, 2aw4, 2awb, 3ofd, 3og0 - EcRPL2 in 50S subunit+5S RRNA+23S RRNA 3fik, 2gya, 2gyc, 3bbx, 1p85, 1p86 - EcRPL2 in 50S subunit+5S RRNA+23S RRNA – Cryo-EM 3kcr - EcRPL2 in 50S subunit+5S RRNA+23S RRNA+preprotein translocase 2rdo - EcRPL2 in 50S subunit+5S RRNA+23S RRNA+EF-G+RRF – Cryo-EM 3bbo - RPL2 in 50S subunit+5S RRNA+23S RRNA+4.8S RRNA – Cryo-EM – spinach 3iy9 – RPL2 in 50S subunit – Leishmania taretolae 2zjq, 2zjr - DrRPL2 in 50S subunit+5S RRNA+23S RRNA – Deinococcus radiodurans 1kqs, 1qvg - HmRPL2P in 50S subunit+5S RRNA+23S RRNA+CCA - Haloarcula marismortui 1jj2, 1ffk, 3cc2, 2qa4, 1s72 - HmRPL2P in 50S subunit+5S RRNA+23S RRNA 3cc7, 3cce, 3ccj, 3ccl, 3ccm, 3ccq, 3ccr, 3ccs, 3ccu, 3ccv - HmRPL2P in 50S subunit+5S RRNA+23S RRNA (mutant) 1vq4, 1vq5, 1vq7, 1vql, 1vqm, 1vqp - HmRPL2P in 50S subunit+5S RRNA+23S RRNA+transition state analog 1vq6, 1vqk, 1vqn - HmRPL2P in 50S subunit+5S RRNA+23S RRNA+ c-hpmn+CCA-Phe-caproic acid-biotin 1vqo - HmRPL2P in 50S subunit+5S RRNA+23S RRNA+ CCPMN 1yhq, 1yi2, 1yij, 1yjn, 1yjw - HmRPL2P in 50S subunit+5S RRNA+23S RRNA (mutant)+antibiotic 1yj9 - HmRPL2P in 50S subunit (L22 mutant)+5S RRNA+23S RRNA 1qvf - HmRPL2P in 50S subunit+5S RRNA+23S RRNA + deacylated tRNA minihelix 1q86 - HmRPL2P in 50S subunit+5S RRNA+23S RRNA+CCA-Phe-caproic acid-biotin


L2 in 50S subunit + antibiotics

3cxc – RPL2 in 50S subunit+5S RRNA+23S RRNA+oxazolidinone inhibitor – Halobacterium marismortui 3dll - DrRPL2 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+oxazolidinone inhibitor 2zjp - DrRPL2 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+nosiheptide 3cf5 - DrRPL2 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+thiostrepton 1xbp - DrRPL2 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+thiamulin 1sm1 - DrRPL2 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+quinupristin+dalfopristin 1nwx - DrRPL2 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+ABT-773 1nwy - DrRPL2 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+azithromycin 3oh5, 3oh7 - TtRPL2 in 50S subunit+5S RRNA+23S RRNA+chloramphenicol 3ohj, 3ohk - TtRPL2 in 50S subunit+5S RRNA+23S RRNA+erythromycin 3ohz, 3oi1 - TtRPL2 in 50S subunit+5S RRNA+23S RRNA+azithromycin 3oi3, 3oi5 - TtRPL2 in 50S subunit+5S RRNA+23S RRNA+telithromycin 2qam, 2qao, 2qoz, 2qp1 - EcRPL2 in 50S subunit+5S RRNA+23S RRNA+neomycin 2qba, 2qbc - EcRPL2 in 50S subunit+5S RRNA+23S RRNA+gentamicin 3ofc - EcRPL2 in 50S subunit+5S RRNA+23S RRNA+chloramphenicol 3ofz - EcRPL2 in 50S subunit+5S RRNA+23S RRNA+clindamycin 3ofq, 3ofr - EcRPL2 in 50S subunit+5S RRNA+23S RRNA+erythromycin 1vt2, 3orb - EcRPL2 in 50S subunit+5S RRNA+23S RRNA+CEM-101 1k73, 1kc8, 1k8a, 1k9m, 1kd1, 1m1k, 3i55, 3i56, 3g4s, 3g6e, 3g71, 2qex, 3cpw, 3cc4, 3cd6, 2otj, 2otl, 1yit, 1q7y, 1q81, 1q82, 1n8r, 1nji - HmRPL2P in 50S subunit+5S RRNA+23S RRNA+antibiotics 1m90, 3cma, 3cme, 1vq8, 1vq9 - HmRPL2P in 50S subunit+5S RRNA+23S RRNA+ sparsomycin+CCA-Phe-caproic acid-biotin


L2 in 60S subunit

3jyw - RPL2 in 60S subunit – Thermomyces lanuginosus – Cryo-EM 2ftc - RPL2 in 60S subunit+16S RRNA - bovine 1s1i - yRPL2 in 40S ribosomal subunit+18S RRNA+elongation factor 2 – Cryo-EM – yeast


L2 in part of the large ribosomal subunit

487d – RPL2+RPL1+RPL6+RPL9+RPL11+RPL14+RPL25 - Cryo-EM 1c04 – HmRPL2P+RPL6+RPL11+RPS14+23S RRNA fragment


L2 in large + small ribosomal subunit

1ml5 - EcRPL2 in 50S ribosomal subunit+30S ribosomal subunit+THX+chain release factor 2+P-site tRNA+tRNA Phe+mRNA fragment+23S RRNA+5S RRNA+16S RRNA – EM


L2 in 50S subunit + ribosome releasing factor (RRF)

2qbe, 2qbg, 2qbi, 2qbk, 2z4l, 2z4n - EcRPL2 in 50S subunit+5S RRNA+23S RRNA+RRF


L2 in 50S subunit + various proteins

2vhm - EcRPL2 in 50S subunit+5S RRNA+23S RRNA+PDF C-terminal helix 2j28 - EcRPL2 in 50S subunit+5S RRNA+23S RRNA+signal recognition particle – Cryo-EM 1vor, 1vou, 1vow, 1voy, 1vp0, 1pnu, 1pny - EcRPL2 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc 1nkw - DrRPL2 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc 1w2b - HmRPL2P in 50S subunit+5S RRNA+23S RRNA+trigger factor N-terminal

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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