User:Wayne Decatur/Homology Modeling

From Proteopedia

Revision as of 02:04, 3 February 2011

• Homology modeling page at Proteopedia
• Eric Martz's Homology modeling of DnaC
• SwissModel
  • Swiss-PdbViewer is tightly linked to SWISS-MODEL, an automated homology modeling server developed within the Swiss Institute of Bioinformatics (SIB) at the Structural Bioinformatics Group at... Swiss-PdbViewer is tightly linked to SWISS-MODEL, an automated homology modeling server developed within the Swiss Institute of Bioinformatics (SIB) at the Structural Bioinformatics Group at the Biozentrum in Basel.
  • Gale Rhodes Homology modeling tutorial using Swiss PDB Viewer (DeepView)
• ModBase: Database of Comparative Protein Structure Models also allows users to calculate comparative models on demand.
  • Modeller is associated with ModBase
• The Homology Modeling Automatically (HOMA) web site
• YASARA - Yet Another Scientific Artificial Reality Application) features a complete homology modeling module that fully automatically takes all the steps from an amino acid sequence to a refined high-resolution model using a CASP approved protocol.
  • Yasara to homology model
• SAM-T08: HMM-based structure prediction.
  • Interesting note on the site page "This server was tested as SAM_T08_server in the CASP8 experiment. Preliminary results indicate that it is a good primary server, but that metaservers combining results from several primary servers are likely to produce somewhat better results."
  • As per the site-"This server finds similar protein sequences in NR and aligns them, providing sequence logos that show relative conservation of different positions. Local structure predictions are done with neural nets for several different local structure alphabets, and hidden Markov models are created. Fold recognition and alignment to proteins in the Protein Data Bank are done, and a full three-dimensional model is constructed. Look carefully at the E-values for the best hits, as full 3D models are constructed even when the E-values are high (and the resulting models are not then not trustworthy)."
• David Bevan's homology modeling page
• I-Tasser:
  • Employs more of comparative protein modelling based on protein threading and not a homology model from what I gather
  • "I-Tasser is an Internet service for protein structure and function predictions. 3D models are built based on multiple-threading alignments by LOMETS and iterative TASSER simulations; function insights are then derived by matching the predicted models with protein function databases. I-TASSER (as 'Zhang-Server') was ranked as the No 1 server for protein structure prediction in recent CASP7 and CASP8 experiments. The server is in active development with the goal to provide the most accurate structural and function predictions using state-of-the-art algorithms."
  • Feb. 2011 Biotechniques article about the P.I. behind this server, Yang Zhang.
• Course on Homology Modeling
• Class on Homology Modeling
• Biskit that uses python for homology modeling
• note on Pymol for homology modeling
• Good summary of the best groups and servers from the CASP8 results

See Also

• Homology model
• Molecular modeling and visualization software
• List of software for molecular mechanics modeling at Wikipeida although thoroughness and how current it is are subject to question by the inclusion of RasMol which is simply a viewer with no modeling abilities that has been supplanted by better viewers such as Chime and Jmol not included on the list.