SARS Coronavirus Main Proteinase
From Proteopedia
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| - | == | + | ==Coronaviruses== |
| - | + | Coronaviruses are enveloped, positive-sense RNA viruses and are the second most prevalent cause of the common cold (rhinoviruses are the first). These viruses have the longest non-segmented RNA genomes currently known, ranging from 27 to 31 kb. Translation of the genome occurs in two phases: (1) the early phase were the viral replicase complex is assembled, and (2) the late phase, structural and nonstructural proteins are translated from a negative-sense RNA template. The maturation of the RNA polymerase is achieved through extensive proteolytic processing by three cysteine peptidases. Two are papain-like proteases (PLpro) and the third is the main protease, also known as the 3C-like protease or 3Clpro | |
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| + | ==SARS== | ||
| + | SARS, severe acute respiratory syndrome | ||
| + | There has been one near pandemic to date, between the months of November 2002 and July 2003, with 8,096 known infected cases and 774 confirmed human deaths (a case-fatality rate of 9.6%) worldwide being listed in the World Health Organization's (WHO) 21 April 2004 concluding report. Started off in China, and cases were reported in 37 countries. When the virus causes pneumonia the mortality rate is 70%. While the outbreak was controlled, we do not know what the reservoir as and has the potential to reemerge. It can infect birds, livestock, and pets. Genetic comparison revealed this virus as a completely new coronavirus (+ strand, RNA viruses, ) | ||
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Replace the PDB id (use lowercase!) after the STRUCTURE_ and after PDB= to load | Replace the PDB id (use lowercase!) after the STRUCTURE_ and after PDB= to load | ||
Revision as of 20:58, 16 November 2010
Coronaviruses
Coronaviruses are enveloped, positive-sense RNA viruses and are the second most prevalent cause of the common cold (rhinoviruses are the first). These viruses have the longest non-segmented RNA genomes currently known, ranging from 27 to 31 kb. Translation of the genome occurs in two phases: (1) the early phase were the viral replicase complex is assembled, and (2) the late phase, structural and nonstructural proteins are translated from a negative-sense RNA template. The maturation of the RNA polymerase is achieved through extensive proteolytic processing by three cysteine peptidases. Two are papain-like proteases (PLpro) and the third is the main protease, also known as the 3C-like protease or 3Clpro
SARS
SARS, severe acute respiratory syndrome There has been one near pandemic to date, between the months of November 2002 and July 2003, with 8,096 known infected cases and 774 confirmed human deaths (a case-fatality rate of 9.6%) worldwide being listed in the World Health Organization's (WHO) 21 April 2004 concluding report. Started off in China, and cases were reported in 37 countries. When the virus causes pneumonia the mortality rate is 70%. While the outbreak was controlled, we do not know what the reservoir as and has the potential to reemerge. It can infect birds, livestock, and pets. Genetic comparison revealed this virus as a completely new coronavirus (+ strand, RNA viruses, )
Replace the PDB id (use lowercase!) after the STRUCTURE_ and after PDB= to load
and display another structure.
Proteopedia Page Contributors and Editors (what is this?)
Sarra Borhanian, Michal Harel, David Canner, Ann Taylor, Alexander Berchansky
