3pgy
From Proteopedia
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{{STRUCTURE_3pgy| PDB=3pgy | SCENE= }} | {{STRUCTURE_3pgy| PDB=3pgy | SCENE= }} | ||
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===Serine hydroxymethyltransferase from Staphylococcus aureus, S95P mutant.=== | ===Serine hydroxymethyltransferase from Staphylococcus aureus, S95P mutant.=== | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/GLYA_STAAC GLYA_STAAC]] Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity).[HAMAP-Rule:MF_00051] | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[3pgy]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PGY OCA]. | |
[[Category: Glycine hydroxymethyltransferase]] | [[Category: Glycine hydroxymethyltransferase]] | ||
[[Category: Staphylococcus aureus]] | [[Category: Staphylococcus aureus]] | ||
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[[Category: Structural genomic]] | [[Category: Structural genomic]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Nov 18 00:56:58 2010'' | ||
Revision as of 08:18, 8 May 2013
Serine hydroxymethyltransferase from Staphylococcus aureus, S95P mutant.
Function
[GLYA_STAAC] Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity).[HAMAP-Rule:MF_00051]
About this Structure
3pgy is a 4 chain structure with sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.
Categories: Glycine hydroxymethyltransferase | Staphylococcus aureus | Anderson, W F. | CSGID, Center for Structural Genomics of Infectious Diseases. | Joachimiak, A. | Kwon, K. | Makowska-Grzyska, M. | Osipiuk, J. | Center for structural genomics of infectious disease | Csgid | Idp00749 | Serine hydroxymethyltransferase | Structural genomic | Transferase
