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Leucine-rich repeat

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A large family of over 60,000 proteins feature horseshoe- or arc-shaped domains made of leucine-rich repeats, which are named for a repeated motif that always contains leucine.<ref>PMID: 20825685</ref>
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A large family of over 60,000 proteins found in viruses, bacteria, archaea, and eukaryotes that feature horseshoe- or arc-shaped domains made of a repeating motif called the leucine-rich repeats because the repeated motif that always contains leucine.<ref>PMID: 20825685</ref>
{{Structure
{{Structure
|PDB= 3e6j |SIZE=400|SCENE=Lamprey_Variable_Lymphocyte_Receptor/Defaultjmol/1|CAPTION= Lamprey Variable Lymphocyte Receptor ([[3e6j]]), resolution 1.67&Aring; (<scene name='Lamprey_Variable_Lymphocyte_Receptor/Defaultjmol/1'>initial scene</scene>)
|PDB= 3e6j |SIZE=400|SCENE=Lamprey_Variable_Lymphocyte_Receptor/Defaultjmol/1|CAPTION= Lamprey Variable Lymphocyte Receptor ([[3e6j]]), resolution 1.67&Aring; (<scene name='Lamprey_Variable_Lymphocyte_Receptor/Defaultjmol/1'>initial scene</scene>)

Revision as of 03:10, 19 November 2010

A large family of over 60,000 proteins found in viruses, bacteria, archaea, and eukaryotes that feature horseshoe- or arc-shaped domains made of a repeating motif called the leucine-rich repeats because the repeated motif that always contains leucine.[1]

PDB ID 3e6j

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Lamprey Variable Lymphocyte Receptor (3e6j), resolution 1.67Å ()
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Articles in Proteopedia concerning Leucine-rich repeat proteins include:



PDB ID 1xwd

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1xwd, resolution 2.92Å ()
Ligands: , ,
Gene: CGA (Homo sapiens), FSHB (Homo sapiens), FSHR (Homo sapiens)
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml


To view automatically seeded indices concerning Leucine-rich repeat proteins, see:

References

  1. ↑ Matsushima N, Miyashita H, Mikami T, Kuroki Y. A nested leucine rich repeat (LRR) domain: the precursor of LRRs is a ten or eleven residue motif. BMC Microbiol. 2010 Sep 9;10:235. PMID:20825685 doi:10.1186/1471-2180-10-235

See Also

Additional Literature

  • Kobe B, Kajava AV. The leucine-rich repeat as a protein recognition motif. Curr Opin Struct Biol. 2001 Dec;11(6):725-32. PMID:11751054
  • Matsushima N, Tanaka T, Enkhbayar P, Mikami T, Taga M, Yamada K, Kuroki Y. Comparative sequence analysis of leucine-rich repeats (LRRs) within vertebrate toll-like receptors. BMC Genomics. 2007 May 21;8:124. PMID:17517123 doi:10.1186/1471-2164-8-124
  • Matsushima N, Tachi N, Kuroki Y, Enkhbayar P, Osaki M, Kamiya M, Kretsinger RH. Structural analysis of leucine-rich-repeat variants in proteins associated with human diseases. Cell Mol Life Sci. 2005 Dec;62(23):2771-91. PMID:16231091 doi:10.1007/s00018-005-5187-z
  • Kajava AV, Kobe B. Assessment of the ability to model proteins with leucine-rich repeats in light of the latest structural information. Protein Sci. 2002 May;11(5):1082-90. PMID:11967365 doi:10.1110/ps.4010102

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Wayne Decatur, Jaime Prilusky, Michal Harel

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