Sandbox c30
From Proteopedia
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[http://www.google.com google] | [http://www.google.com google] | ||
| - | <Structure load='1ACJ' size='300' frame='true' align='right' caption='Tacrine' / | + | <Structure load='1ACJ' size='300' frame='true' align='right' caption='Tacrine' / |
Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor. | Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor. | ||
| - | It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease. | + | It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease.<scene name='Sandbox_c30/Inhibidor/3'>(w84- Y330)</scene> |
| - | Tacrine’s ring is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330.<scene name='Sandbox_c30/Inhibidor/1'>(W84 and F330)</scene> | ||
| - | Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649 | + | |
| + | <ref></ref>Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649 | ||
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| + | <references/> | ||
Revision as of 13:23, 23 November 2010
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