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	Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor.		Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor.
	It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease. Tacrine’s ring is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330		It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease. Tacrine’s ring is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330
-	<scene name='Sandbox_c2/Tacrine1/1'>(W84 and F330)</scene>.	+	<scene name='Sandbox_c2/Tacrine1/1'>(W84 and F330)</scene>.<Ref>PMID 8415649</ref>
-	Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase.'	+	Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase.'<references/>

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Revision as of 13:25, 23 November 2010

spinqualitylabelsall models caption Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

1ACJ shows the crystal structure of Torpedo californica acetylcholinesterase (TcAChE) complexed with tacrine.

Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor. It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease. Tacrine’s ring is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330 .^[1]

Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase.'

1. ↑ Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649