Sandbox c8

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Tacrine’s ring is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330
Tacrine’s ring is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330
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<scene name='Sandbox_c8/Proteina/1'>(W84 and F330).</scene>
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<scene name='Sandbox_c8/Proteina/1'>(W84 and F330).</scene> <ref>PMID:8415649<<ref>
Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding
Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding
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<references/>

Revision as of 13:24, 23 November 2010

Estructura

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1ACJ shows the crystal structure of Torpedo californica acetylcholinesterase (TcAChE) complexed with tacrine.

Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor.

It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease.

Tacrine’s ring is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330 [1]

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