Sandbox c16
From Proteopedia
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It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease. | It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease. | ||
| - | <scene name='Sandbox_c16/Modificacion_2/1'> | + | <scene name='Sandbox_c16/Modificacion_2/1'>Tacrine</scene> ring is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330 (<scene name='Sandbox_c16/Modificacion_1/1'>W84 and F330</scene> ). |
<references/> | <references/> | ||
Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding <ref>PMDI 8415649</ref> | Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding <ref>PMDI 8415649</ref> | ||
[http://www.pubmed.com publicaciones medicas] <references/> | [http://www.pubmed.com publicaciones medicas] <references/> | ||
Revision as of 13:27, 23 November 2010
Estructura acetilcolinesterasa
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1ACJ shows the crystal structure of Torpedo californica acetylcholinesterase (TcAChE) complexed with tacrine. Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor.
It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease.
ring is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330 ( ).
Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding [1]
- ↑ PMDI 8415649
