Tol
From Proteopedia
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==Regulation== | ==Regulation== | ||
| - | It has been shown that the regulation of Tol genes is linked to the cell envelope stability. <ref> | + | It has been shown that the regulation of Tol genes is linked to the cell envelope stability. <ref>PMCID: PMC1847374 </ref> In studies with E. coli, the ''tol-pal'' genes have been induced by RcsC in response to cell envelope stress. <ref>http://www.ncbi.nlm.nih.gov/pubmed/8821933 </ref> RcsC is a transmembrane sensor kinase, and along with the cytoplasmic response regulator RcsB, makes up the RcsBC regulatory system. <ref>http://jb.asm.org/cgi/content/abstract/187/19/6770 </ref> RcsBC is involved in the regulation of ''cps'' genes which code for the biosynthsis machinery of a major componant for the capsula, cholanic acid. |
== References== | == References== | ||
<references/> | <references/> | ||
Revision as of 17:07, 3 December 2010
The Tol system, also known as Tol-Pal, is a multiprotein complex found in the cell envelope of many gram-negative bacteria. It contains 7 proteins (TolQ, TolR, TolA, TolB, Pal, YbgF, YbgC) organised into two operons.
Contents |
Structure
Function
Regulation
It has been shown that the regulation of Tol genes is linked to the cell envelope stability. [1] In studies with E. coli, the tol-pal genes have been induced by RcsC in response to cell envelope stress. [2] RcsC is a transmembrane sensor kinase, and along with the cytoplasmic response regulator RcsB, makes up the RcsBC regulatory system. [3] RcsBC is involved in the regulation of cps genes which code for the biosynthsis machinery of a major componant for the capsula, cholanic acid.
