Cyclooxygenase

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! Coefficient of selectivity (IC50Cox-1/IC50Cox-2)
! Coefficient of selectivity (IC50Cox-1/IC50Cox-2)
|-
|-
-
| row 1, cell 1
+
| Ketorolac
-
| row 1, cell 2
+
| 100-1000
|-
|-
-
| row 2, cell 1
+
| Naproxen
-
| row 2, cell 2
+
| 1-10
|-
|-
-
| row 3, cell 1
+
| Ibuprofen
-
| row 3, cell 2
+
| 1-10
|-
|-
-
| row 4, cell 1
+
| Indometacin
-
| row 4, cell 2
+
| 1-10
 +
|-
 +
| Acetylsalicylic acid
 +
| 1
 +
|-
 +
| Diclofenac
 +
| 1-0.1
 +
|-
 +
| Valdecoxib
 +
| 0.01-0.001
 +
|-
 +
| Etoricoxib
 +
| 0.01-0.001
|}
|}

Revision as of 10:32, 6 December 2010

Image:6cox.png

Template:STRUCTURE 6cox

Contents

Crystal structure of COX-2

About this Structure

2I37 is a 3 chains structure of sequences from Bos taurus. Full crystallographic information is available from OCA.

NSAIDs

Drug Coefficient of selectivity (IC50Cox-1/IC50Cox-2)
Ketorolac 100-1000
Naproxen 1-10
Ibuprofen 1-10
Indometacin 1-10
Acetylsalicylic acid 1
Diclofenac 1-0.1
Valdecoxib 0.01-0.001
Etoricoxib 0.01-0.001


Reference

  • Salom D, Lodowski DT, Stenkamp RE, Le Trong I, Golczak M, Jastrzebska B, Harris T, Ballesteros JA, Palczewski K. Crystal structure of a photoactivated deprotonated intermediate of rhodopsin. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16123-8. Epub 2006 Oct 23. PMID:17060607

Page seeded by OCA on Tue Feb 17 02:59:53 2009

  • Ghosh N, Chaki R, Mandal V, Mandal SC. COX-2 as a target for cancer chemotherapy. Pharmacol Rep. 2010 Mar-Apr;62(2):233-44. PMID:20508278
  • Rang HP, Dale MM, Ritter JM, Flower RJ. 2008. Pharmacology. Elsevier. 6th edition. 844 p.
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