3bd0
From Proteopedia
(New page: 200px<br /><applet load="3bd0" size="350" color="white" frame="true" align="right" spinBox="true" caption="3bd0, resolution 3.010Å" /> '''Crystal structure o...) |
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caption="3bd0, resolution 3.010Å" /> | caption="3bd0, resolution 3.010Å" /> | ||
'''Crystal structure of Memo, form II'''<br /> | '''Crystal structure of Memo, form II'''<br /> | ||
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| + | ==Overview== | ||
| + | Memo (mediator of ErbB2-driven cell motility) is a 297-amino-acid protein, recently shown to co-precipitate with the C terminus of ErbB2 and be, required for ErbB2-driven cell motility. Memo is not homologous to any, known signaling proteins, and how it mediates ErbB2 signals is not known., To provide a molecular basis for understanding Memo function, we have, determined and report here the 2.1A crystal structure of human Memo and, show it be homologous to class III nonheme iron-dependent dioxygenases, a, structural class that now includes a zinc-binding protein of unknown, function. No metal binding or enzymatic activity can be detected for Memo, but Memo does bind directly to a specific ErbB2-derived phosphopeptide, encompassing Tyr-1227 using its vestigial enzymatic active site. Memo thus, represents a new class of phosphotyrosine-binding protein. | ||
==About this Structure== | ==About this Structure== | ||
3BD0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=PEG:'>PEG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BD0 OCA]. | 3BD0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=PEG:'>PEG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BD0 OCA]. | ||
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| + | ==Reference== | ||
| + | Memo Is Homologous to Nonheme Iron Dioxygenases and Binds an ErbB2-derived Phosphopeptide in Its Vestigial Active Site., Qiu C, Lienhard S, Hynes NE, Badache A, Leahy DJ, J Biol Chem. 2008 Feb 1;283(5):2734-40. Epub 2007 Nov 28. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18045866 18045866] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: peptide binding protein]] | [[Category: peptide binding protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 13 08:18:55 2008'' |
Revision as of 06:18, 13 February 2008
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Crystal structure of Memo, form II
Overview
Memo (mediator of ErbB2-driven cell motility) is a 297-amino-acid protein, recently shown to co-precipitate with the C terminus of ErbB2 and be, required for ErbB2-driven cell motility. Memo is not homologous to any, known signaling proteins, and how it mediates ErbB2 signals is not known., To provide a molecular basis for understanding Memo function, we have, determined and report here the 2.1A crystal structure of human Memo and, show it be homologous to class III nonheme iron-dependent dioxygenases, a, structural class that now includes a zinc-binding protein of unknown, function. No metal binding or enzymatic activity can be detected for Memo, but Memo does bind directly to a specific ErbB2-derived phosphopeptide, encompassing Tyr-1227 using its vestigial enzymatic active site. Memo thus, represents a new class of phosphotyrosine-binding protein.
About this Structure
3BD0 is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Memo Is Homologous to Nonheme Iron Dioxygenases and Binds an ErbB2-derived Phosphopeptide in Its Vestigial Active Site., Qiu C, Lienhard S, Hynes NE, Badache A, Leahy DJ, J Biol Chem. 2008 Feb 1;283(5):2734-40. Epub 2007 Nov 28. PMID:18045866
Page seeded by OCA on Wed Feb 13 08:18:55 2008
