NSAID Pharmacokinetics

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Line 25:		Line 25:
	! 2.29		! 2.29
	! Acetylsalicylic Acid (Aspirin)		! Acetylsalicylic Acid (Aspirin)
-	! Valdecoxib (Bextra)	+	! 2.94
	! Celecoxib (Celebrex)		! Celecoxib (Celebrex)
	! Sulindac (Clinoril)		! Sulindac (Clinoril)
Line 42:		Line 42:
	! 19670		! 19670
	! Acetylsalicylic Acid (Aspirin)		! Acetylsalicylic Acid (Aspirin)
-	! Valdecoxib (Bextra)	+	! 340
	! Celecoxib (Celebrex)		! Celecoxib (Celebrex)
	! Sulindac (Clinoril)		! Sulindac (Clinoril)
Line 110:		Line 110:
	! 124320		! 124320
	! Acetylsalicylic Acid (Aspirin)		! Acetylsalicylic Acid (Aspirin)
-	! Valdecoxib (Bextra)	+	! 7548
	! Celecoxib (Celebrex)		! Celecoxib (Celebrex)
	! Sulindac (Clinoril)		! Sulindac (Clinoril)
Line 178:		Line 178:
	! 150		! 150
	! Acetylsalicylic Acid (Aspirin)		! Acetylsalicylic Acid (Aspirin)
-	! Valdecoxib (Bextra)	+	! 20
	! Celecoxib (Celebrex)		! Celecoxib (Celebrex)
	! Sulindac (Clinoril)		! Sulindac (Clinoril)

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Revision as of 19:13, 9 December 2010

Cyclooxygenase Inhibitor Pharmacokinetics
Parameter	Ibuprofen (Advil)	Naproxen (Aleve)	Flurbiprofen (Ansaid)	Acetylsalicylic Acid (Aspirin)	Valdecoxib (Bextra)	Celecoxib (Celebrex)	Sulindac (Clinoril)	Oxaprozin (Daypro)	Piroxicam (Feldene)	Nabumetone (Relafen)	Acetaminophen (Paracetamol)	Mefanamic Acid (Ponstel)	Ketorolac (Toradol)	Rofecoxib (Vioxx)	Diclofenac (Voltaren)
Tmax (hr)	1.3	.92	2.29	Acetylsalicylic Acid (Aspirin)	2.94	Celecoxib (Celebrex)	Sulindac (Clinoril)	Oxaprozin (Daypro)	Piroxicam (Feldene)	Nabumetone (Relafen)	Acetaminophen (Paracetamol)	Mefanamic Acid (Ponstel)	Ketorolac (Toradol)	Rofecoxib (Vioxx)	Diclofenac (Voltaren)
Cmax (ng/ml)	16200	47100	19670	Acetylsalicylic Acid (Aspirin)	340	Celecoxib (Celebrex)	Sulindac (Clinoril)	Oxaprozin (Daypro)	Piroxicam (Feldene)	Nabumetone (Relafen)	Acetaminophen (Paracetamol)	Mefanamic Acid (Ponstel)	Ketorolac (Toradol)	Rofecoxib (Vioxx)	Diclofenac (Voltaren)
Bioavailability (%)	49-73	95	Flurbiprofen (Ansaid)	Acetylsalicylic Acid (Aspirin)	Valdecoxib (Bextra)	Celecoxib (Celebrex)	Sulindac (Clinoril)	Oxaprozin (Daypro)	Piroxicam (Feldene)	Nabumetone (Relafen)	Acetaminophen (Paracetamol)	Mefanamic Acid (Ponstel)	Ketorolac (Toradol)	Rofecoxib (Vioxx)	Diclofenac (Voltaren)
Protein Binding (%)	99	99	Flurbiprofen (Ansaid)	Acetylsalicylic Acid (Aspirin)	Valdecoxib (Bextra)	Celecoxib (Celebrex)	Sulindac (Clinoril)	Oxaprozin (Daypro)	Piroxicam (Feldene)	Nabumetone (Relafen)	Acetaminophen (Paracetamol)	Mefanamic Acid (Ponstel)	Ketorolac (Toradol)	Rofecoxib (Vioxx)	Diclofenac (Voltaren)
T1/2 (hr)	2.4	18.7	4.77	Acetylsalicylic Acid (Aspirin)	Valdecoxib (Bextra)	Celecoxib (Celebrex)	Sulindac (Clinoril)	Oxaprozin (Daypro)	Piroxicam (Feldene)	Nabumetone (Relafen)	Acetaminophen (Paracetamol)	Mefanamic Acid (Ponstel)	Ketorolac (Toradol)	Rofecoxib (Vioxx)	Diclofenac (Voltaren)
AUC (ng/ml/hr)	67400	777400	124320	Acetylsalicylic Acid (Aspirin)	7548	Celecoxib (Celebrex)	Sulindac (Clinoril)	Oxaprozin (Daypro)	Piroxicam (Feldene)	Nabumetone (Relafen)	Acetaminophen (Paracetamol)	Mefanamic Acid (Ponstel)	Ketorolac (Toradol)	Rofecoxib (Vioxx)	Diclofenac (Voltaren)
IC50 COX-1 (nM)	18	11	Flurbiprofen (Ansaid)	342	Valdecoxib (Bextra)	Celecoxib (Celebrex)	Sulindac (Clinoril)	Oxaprozin (Daypro)	Piroxicam (Feldene)	Nabumetone (Relafen)	Acetaminophen (Paracetamol)	Mefanamic Acid (Ponstel)	Ketorolac (Toradol)	Rofecoxib (Vioxx)	Diclofenac (Voltaren)
IC50 COX-2 (nM)	1030	1015	Flurbiprofen (Ansaid)	>5000	Valdecoxib (Bextra)	Celecoxib (Celebrex)	Sulindac (Clinoril)	Oxaprozin (Daypro)	Piroxicam (Feldene)	Nabumetone (Relafen)	Acetaminophen (Paracetamol)	Mefanamic Acid (Ponstel)	Ketorolac (Toradol)	Rofecoxib (Vioxx)	Diclofenac (Voltaren)
Clearance (L/h)	3.4	Naproxen (Aleve)	Flurbiprofen (Ansaid)	Acetylsalicylic Acid (Aspirin)	Valdecoxib (Bextra)	Celecoxib (Celebrex)	Sulindac (Clinoril)	Oxaprozin (Daypro)	Piroxicam (Feldene)	Nabumetone (Relafen)	Acetaminophen (Paracetamol)	Mefanamic Acid (Ponstel)	Ketorolac (Toradol)	Rofecoxib (Vioxx)	Diclofenac (Voltaren)
Dosage (mg)	400	200	150	Acetylsalicylic Acid (Aspirin)	20	Celecoxib (Celebrex)	Sulindac (Clinoril)	Oxaprozin (Daypro)	Piroxicam (Feldene)	Nabumetone (Relafen)	Acetaminophen (Paracetamol)	Mefanamic Acid (Ponstel)	Ketorolac (Toradol)	Rofecoxib (Vioxx)	Diclofenac (Voltaren)
Metabolism	Hepatic (CYP2C9)	Naproxen (Aleve)	Flurbiprofen (Ansaid)	Acetylsalicylic Acid (Aspirin)	Valdecoxib (Bextra)	Celecoxib (Celebrex)	Sulindac (Clinoril)	Oxaprozin (Daypro)	Piroxicam (Feldene)	Nabumetone (Relafen)	Acetaminophen (Paracetamol)	Mefanamic Acid (Ponstel)	Ketorolac (Toradol)	Rofecoxib (Vioxx)	Diclofenac (Voltaren)

For references, see: References