User:Genevieve Abbruzzese/Sandbox 1
From Proteopedia
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| - | ADAM13 | + | *[[User:Genevieve Abbruzzese/Sandbox 1]] |
| - | <scene name='User:Genevieve_Abbruzzese/ | + | <applet size='[450,338]' frame='true' align='right' |
| + | caption='ADAM13 homology model' | ||
| + | <scene name='User:Genevieve_Abbruzzese/A13mdce/4'>ADAM13 modeled against ADAM22</scene> | ||
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| + | One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground]. | ||
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| + | ADAM13 is a transmembrane protein containing a metalloprotease (gray) and controls cell motility by shedding adhesion molecules from the cell surface. ADAM13 also exhibits adhesive activity through it's disintegrin (blue) and cysteine rich (purple) domains (EGF-like repeat, cyan). | ||
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| + | === Metalloprotease domain === | ||
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| + | Most ADAMs contain a canonical metalloprotease site (HExxHxxGxxH) with a catalytic glutamate residue (shown in red) three Histidine residues (blue) coordinating a Zinc ion (green). | ||
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| + | [[Image:ADAM33metallo.png]] | ||
Revision as of 03:55, 10 December 2010
- User:Genevieve Abbruzzese/Sandbox 1
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