2jsd
From Proteopedia
(New page: 200px<br /><applet load="2jsd" size="350" color="white" frame="true" align="right" spinBox="true" caption="2jsd" /> '''Solution structure of MMP20 complexed with N...) |
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==Overview== | ==Overview== | ||
| - | The solution structure of the catalytic domain of MMP-20, a member of the | + | The solution structure of the catalytic domain of MMP-20, a member of the matrix metalloproteinases family not yet structurally characterized, complexed with N-Isobutyl-N-(4-methoxyphenylsulfonyl)glycyl hydroxamic acid (NNGH), is here reported and compared with other MMPs-NNGH adducts. The backbone dynamic has been characterized as well. We have found that, despite the same fold and very high overall similarity, the present structure experiences specific structural and dynamical similarities with some MMPs and differences with others, around the catalytic cavity. The present solution structure, not only contributes to fill the gap of structural knowledge on human MMPs, but also provides further information to design more selective and efficient inhibitors for a specific member of this class of proteins. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Bertini, I.]] | [[Category: Bertini, I.]] | ||
[[Category: Cantini, F.]] | [[Category: Cantini, F.]] | ||
| - | [[Category: Conte, R | + | [[Category: Conte, R Del.]] |
[[Category: Cozzi, R.]] | [[Category: Cozzi, R.]] | ||
[[Category: Gonnelli, L.]] | [[Category: Gonnelli, L.]] | ||
| - | [[Category: SPINE, Structural | + | [[Category: SPINE, Structural Proteomics in Europe.]] |
[[Category: CA]] | [[Category: CA]] | ||
[[Category: NGH]] | [[Category: NGH]] | ||
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[[Category: structural proteomics in europe]] | [[Category: structural proteomics in europe]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:05:38 2008'' |
Revision as of 16:05, 21 February 2008
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Solution structure of MMP20 complexed with NNGH
Overview
The solution structure of the catalytic domain of MMP-20, a member of the matrix metalloproteinases family not yet structurally characterized, complexed with N-Isobutyl-N-(4-methoxyphenylsulfonyl)glycyl hydroxamic acid (NNGH), is here reported and compared with other MMPs-NNGH adducts. The backbone dynamic has been characterized as well. We have found that, despite the same fold and very high overall similarity, the present structure experiences specific structural and dynamical similarities with some MMPs and differences with others, around the catalytic cavity. The present solution structure, not only contributes to fill the gap of structural knowledge on human MMPs, but also provides further information to design more selective and efficient inhibitors for a specific member of this class of proteins.
About this Structure
2JSD is a Single protein structure of sequence from Homo sapiens with , and as ligands. Full crystallographic information is available from OCA.
Reference
Catalytic domain of MMP20 (Enamelysin) - the NMR structure of a new matrix metalloproteinase., Arendt Y, Banci L, Bertini I, Cantini F, Cozzi R, Del Conte R, Gonnelli L, FEBS Lett. 2007 Oct 2;581(24):4723-6. Epub 2007 Sep 6. PMID:17869250
Page seeded by OCA on Thu Feb 21 18:05:38 2008
Categories: Homo sapiens | Single protein | Arendt, Y. | Banci, L. | Bertini, I. | Cantini, F. | Conte, R Del. | Cozzi, R. | Gonnelli, L. | SPINE, Structural Proteomics in Europe. | CA | NGH | ZN | Hydrolase | Mmp-nngh | Spine | Spine-2 | Spine2-complexes | Structural genomics | Structural proteomics in europe
