This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3l1p
From Proteopedia
| Line 1: | Line 1: | ||
| - | {{Seed}} | ||
| - | [[Image:3l1p.jpg|left|200px]] | ||
| - | |||
| - | <!-- | ||
| - | The line below this paragraph, containing "STRUCTURE_3l1p", creates the "Structure Box" on the page. | ||
| - | You may change the PDB parameter (which sets the PDB file loaded into the applet) | ||
| - | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | ||
| - | or leave the SCENE parameter empty for the default display. | ||
| - | --> | ||
{{STRUCTURE_3l1p| PDB=3l1p | SCENE= }} | {{STRUCTURE_3l1p| PDB=3l1p | SCENE= }} | ||
| - | |||
===POU protein:DNA complex=== | ===POU protein:DNA complex=== | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/PO5F1_MOUSE PO5F1_MOUSE]] Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.<ref>PMID:17496161</ref> <ref>PMID:17525163</ref> | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[3l1p]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L1P OCA]. | |
| + | |||
| + | ==Reference== | ||
| + | <references group="xtra"/><references/> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Groves, M R.]] | [[Category: Groves, M R.]] | ||
| Line 26: | Line 21: | ||
[[Category: Transcription factor dna complex]] | [[Category: Transcription factor dna complex]] | ||
[[Category: Transcription-dna complex]] | [[Category: Transcription-dna complex]] | ||
| - | |||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 15 08:40:47 2010'' | ||
Revision as of 20:14, 4 April 2013
Contents |
POU protein:DNA complex
Function
[PO5F1_MOUSE] Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.[1] [2]
About this Structure
3l1p is a 4 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
- ↑ Zhang Z, Liao B, Xu M, Jin Y. Post-translational modification of POU domain transcription factor Oct-4 by SUMO-1. FASEB J. 2007 Oct;21(12):3042-51. Epub 2007 May 11. PMID:17496161 doi:fj.06-6914com
- ↑ Wei F, Scholer HR, Atchison ML. Sumoylation of Oct4 enhances its stability, DNA binding, and transactivation. J Biol Chem. 2007 Jul 20;282(29):21551-60. Epub 2007 May 24. PMID:17525163 doi:M611041200
