Subtilisin

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: Crystal Structure of Subtilisin 2z2x {{STRUCTURE_2z2x| PDB=2z2x | SIZE=300| SCENE= |right|CAPTION=Subtilisin 2z2x }} Subtilisin is a seri...)
Line 1: Line 1:
[[Image:2z2x.png|left|200px|thumb|Crystal Structure of Subtilisin [[2z2x]]]]
[[Image:2z2x.png|left|200px|thumb|Crystal Structure of Subtilisin [[2z2x]]]]
-
{{STRUCTURE_2z2x| PDB=2z2x | SIZE=300| SCENE= |right|CAPTION=Subtilisin [[2z2x]] }}
+
{{STRUCTURE_2z2x| PDB=2z2x | SIZE=300| SCENE=Subtilisin/Cv/1 |right|CAPTION=Subtilisin [[2z2x]] }}
[[Subtilisin]] is a serine protease. It is widely used commercially in detergents.
[[Subtilisin]] is a serine protease. It is widely used commercially in detergents.
Line 12: Line 12:
=== Native mature subtilisin ===
=== Native mature subtilisin ===
-
2z2x – TkSub - ''Thermococcus kodakarensis''
+
[[2z2x]] – TkSub - ''Thermococcus kodakarensis''<br />
-
1sca, 1scb, 1sbc – BsSub - Bacillus subtilis (Subtilisin Carlsberg)
+
[[1sca]], [[1scb]], [[1sbc]] – BsSub - ''Bacillus subtilis'' (Subtilisin Carlsberg)<br />
-
1gns, 1sup, 1st2, 1st1, 1s01, 1sbt, 2sbt – BaSub - Bacillus amyloliquefaciens
+
[[1gns]], [[1sup]], [[1st2]], [[1st1]], [[1s01]], [[1sbt]], [[2sbt]] – BaSub - ''Bacillus amyloliquefaciens''<br />
-
1iav, 1gci, 1jea, 1st3 – BlSub - Bacillus lentus (Subtilisin Savinase)
+
[[1iav]], [[1gci]], [[1jea]], [[1st3]] – BlSub - ''Bacillus lentus'' (Subtilisin Savinase)<br />
-
1ea7, 3d43, 2ixt – spehricase – Sub from Bacillus sphaericus
+
[[1ea7]], [[3d43]], [[2ixt]] – spehricase – Sub from ''Bacillus sphaericus''
=== Mutant mature subtilisin ===
=== Mutant mature subtilisin ===
-
3f49, 3co0, 2zrq – TkSubb (mutant)
+
[[3f49]], [[3co0]], [[2zrq]] – TkSubb (mutant) <br />
-
1gnv, 1dui, 1sue, 1a2q, 1aqn, 1sua, 1au9, 1ak9, 1yja, 1yjb, 1yjc, 1sbh, 1sbi, 1sub, 1suc, 1sud, 1s02 – BaSub (mutant)
+
[[1gnv]], [[1dui]], [[1sue]], [[1a2q]], [[1aqn]], [[1sua]], [[1au9]], [[1ak9]], [[1yja]], [[1yjb]], [[1yjc]], [[1sbh]], [[1sbi]], [[1sub]], [[1suc]], [[1sud]], [[1s02]] – BaSub (mutant)<br />
-
1ndu, 1q5p, 1c9j, 1c9m, 1c9n – BlSub (mutant)
+
[[1ndu]], [[1q5p]], [[1c9j]], [[1c9m]], [[1c9n]] – BlSub (mutant)
=== Native unautoprocessed subtilisin (pro-Sub) ===
=== Native unautoprocessed subtilisin (pro-Sub) ===
-
2z2z, 2e1p – pro-TkSub
+
[[2z2z]], [[2e1p]] – pro-TkSub
=== Mutant unautoprocessed subtilisin ===
=== Mutant unautoprocessed subtilisin ===
-
2zwo, 2zwp – pro-TKSub
+
[[2zwo]], [[2zwp]] – pro-TKSub
=== Mature subtilisin complexed with its propeptide ===
=== Mature subtilisin complexed with its propeptide ===
-
3cnq – BaSub
+
[[3cnq]] – BaSub<br />
-
1spb – BaSub (mutant)
+
[[1spb]] – BaSub (mutant)<br />
-
3a3n, 3a3o, 3a3p, 2z56, 2z57, 2z58, 2z2y, 2z30 – TkSub
+
[[3a3n]], [[3a3o]], [[3a3p]], [[2z56]], [[2z57]], [[2z58]], [[2z2y]], [[2z30]] – TkSub<br />
-
1scj – BsSub
+
[[1scj]] – BsSub
=== Subtilisin complexed with polypeptide inhibitor ===
=== Subtilisin complexed with polypeptide inhibitor ===
-
1y1k, 1y33, 1y34, 1y3b, 1y3c, 1y3d, 1y3f, 1y48, 1y4a, 1y4d, 1tm3, 1tm4,
+
[[1y1k]], [[1y33]], [[1y34]], [[1y3b]], [[1y3c]], [[1y3d]], [[1y3f]], [[1y48]], [[1y4a]], [[1y4d]], [[1tm3]], [[1tm4]],
-
1tm1, 1lw6 – BaSub+ chymotripsin inhibitor 2
+
[[1tm1]], [[1lw6]] – BaSub+ chymotripsin inhibitor 2<br />
-
3sic, 5sic, 2sic – BaSub+Streptomyces inhibitor SSI
+
[[3sic]], [[5sic]], [[2sic]] – BaSub+Streptomyces inhibitor SSI<br />
-
1yu6 – BsSub+ovomucoid
+
[[1yu6]] – BsSub+ovomucoid <br />
-
1v5i – BaSubb+POIA1 peptide
+
[[1v5i]] – BaSubb+POIA1 peptide <br />
-
1tk2, 1ndq – BlSub+gramicidin S
+
[[1tk2]], [[1ndq]] – BlSub+gramicidin S <br />
-
1r0r – BsSub+ovomucoid
+
[[1r0r]] – BsSub+ovomucoid<br />
-
1oyv – BsSub+tomato inhibitor II
+
[[1oyv]] – BsSub+tomato inhibitor II<br />
-
1sbn, 1sib, 2sec, 1sni, 1sce – BsSub+Elgin C
+
[[1sbn]], [[1sib]], [[2sec]], [[1sni]], [[1sce]] – BsSub+Elgin C<br />
-
1mee - BpSub+Elgin C – Bacillus pumilus
+
[[1mee]] - BpSub+Elgin C – ''Bacillus pumilus''
-
 
+
=== Subtilisin complexed with inhibitor ===
=== Subtilisin complexed with inhibitor ===
-
3bgo – BaSub+azide
+
[[3bgo]] – BaSub+azide <br />
-
1c3l – BsSub+Xe
+
[[1c3l]] – BsSub+Xe<br />
-
1be8 – BsSub+cinnamoyl
+
[[1be8]] – BsSub+cinnamoyl<br />
-
1be6 - BsSub+cinnamoyl+acetonitrile
+
[[1be6]] - BsSub+cinnamoyl+acetonitrile<br />
-
1bfk , 1scd– BsSub+acetonitrile
+
[[1bfk]], [[1scd]] – BsSub+acetonitrile<br />
-
1bfu, 1af4 – BsSub+dioxane
+
[[1bfu]], [[1af4]] – BsSub+dioxane<br />
-
1av7, 1avt, 3vsb, 1vsb – BsSub+boronic acid derivatives
+
[[1av7]], [[1avt]], [[3vsb]], [[1vsb]] – BsSub+boronic acid derivatives <br />
-
1scn – BsSub+carbamate derivative
+
[[1scn]] – BsSub+carbamate derivative <br />
-
1bh6 – Sub DY+benzyloxycarbonyl-ala-pro-phe-chloromethyl ketone –Bacillus licheniformis
+
[[1bh6]] – Sub DY+benzyloxycarbonyl-ala-pro-phe-chloromethyl ketone – ''Bacillus licheniformis''

Revision as of 09:27, 16 December 2010

Image:2z2x.png
Crystal Structure of Subtilisin 2z2x

Template:STRUCTURE 2z2x

Subtilisin is a serine protease. It is widely used commercially in detergents. A 77 amino acid propeptide is cleaved from the N-terminus of pro-Sub to create the mature active enzyme. The images at the left and at the right correspond to one representative Subtilisin, i.e. the crystal structure of native mature subtilisin from Thermococcus kodakarensis (2z2x).

Contents

3D Structures of Subtilisin

Native mature subtilisin

2z2x – TkSub - Thermococcus kodakarensis
1sca, 1scb, 1sbc – BsSub - Bacillus subtilis (Subtilisin Carlsberg)
1gns, 1sup, 1st2, 1st1, 1s01, 1sbt, 2sbt – BaSub - Bacillus amyloliquefaciens
1iav, 1gci, 1jea, 1st3 – BlSub - Bacillus lentus (Subtilisin Savinase)
1ea7, 3d43, 2ixt – spehricase – Sub from Bacillus sphaericus

Mutant mature subtilisin

3f49, 3co0, 2zrq – TkSubb (mutant)
1gnv, 1dui, 1sue, 1a2q, 1aqn, 1sua, 1au9, 1ak9, 1yja, 1yjb, 1yjc, 1sbh, 1sbi, 1sub, 1suc, 1sud, 1s02 – BaSub (mutant)
1ndu, 1q5p, 1c9j, 1c9m, 1c9n – BlSub (mutant)


Native unautoprocessed subtilisin (pro-Sub)

2z2z, 2e1p – pro-TkSub


Mutant unautoprocessed subtilisin

2zwo, 2zwp – pro-TKSub


Mature subtilisin complexed with its propeptide

3cnq – BaSub
1spb – BaSub (mutant)
3a3n, 3a3o, 3a3p, 2z56, 2z57, 2z58, 2z2y, 2z30 – TkSub
1scj – BsSub


Subtilisin complexed with polypeptide inhibitor

1y1k, 1y33, 1y34, 1y3b, 1y3c, 1y3d, 1y3f, 1y48, 1y4a, 1y4d, 1tm3, 1tm4, 1tm1, 1lw6 – BaSub+ chymotripsin inhibitor 2
3sic, 5sic, 2sic – BaSub+Streptomyces inhibitor SSI
1yu6 – BsSub+ovomucoid
1v5i – BaSubb+POIA1 peptide
1tk2, 1ndq – BlSub+gramicidin S
1r0r – BsSub+ovomucoid
1oyv – BsSub+tomato inhibitor II
1sbn, 1sib, 2sec, 1sni, 1sce – BsSub+Elgin C
1mee - BpSub+Elgin C – Bacillus pumilus

Subtilisin complexed with inhibitor

3bgo – BaSub+azide
1c3l – BsSub+Xe
1be8 – BsSub+cinnamoyl
1be6 - BsSub+cinnamoyl+acetonitrile
1bfk, 1scd – BsSub+acetonitrile
1bfu, 1af4 – BsSub+dioxane
1av7, 1avt, 3vsb, 1vsb – BsSub+boronic acid derivatives
1scn – BsSub+carbamate derivative
1bh6 – Sub DY+benzyloxycarbonyl-ala-pro-phe-chloromethyl ketone – Bacillus licheniformis

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Subtilisin"
Personal tools