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Fibrinogen
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Fibrinogen is composed of 2 copies each of 3 non-identical chains alpha, beta, gamma (<scene name='Fibrinogen/Fba/1'>Fba</scene>, <scene name='Fibrinogen/Fbb/1'>Fbb</scene>, <scene name='Fibrinogen/Fbg/1'>Fbg</scene>). | Fibrinogen is composed of 2 copies each of 3 non-identical chains alpha, beta, gamma (<scene name='Fibrinogen/Fba/1'>Fba</scene>, <scene name='Fibrinogen/Fbb/1'>Fbb</scene>, <scene name='Fibrinogen/Fbg/1'>Fbg</scene>). | ||
| - | ===Fibrinogen | + | ===Fibrinogen α+β+γ chains=== |
| - | + | [[3hus]], [[3h32]], [[3e1i]], [[3bvh]], [[2hlo]], [[2hod]], [[2hpc]], [[2oyh]], [[2oyi]], [[2h43]], [[2ffd]], [[1re3]], [[1rf1]], [[1n86]], [[1ltj]] – hFba+hFbb+hFbg+peptide ligand – human<br /> | |
| - | + | [[3ghg]], [[2q9i]], [[2z4e]] - hFba+hFbb+hFbg+knob A & B<br /> | |
| - | + | [[2a45]] - hFba+hFbb+hFbg+thrombin+PPACK thrombin inhibitor<br /> | |
| - | + | [[1re4]], [[1rf0]], [[1n8e]], [[1lt9]] - hFba+hFbb+hFbg<br /> | |
| - | + | [[1jy3]], [[1deq]] – cFba+cFbb+cFbg – cow<br /> | |
| - | + | [[1jy2]] - cFba+cFbb+cFbg proteolytic fragment<br /> | |
| - | + | [[1n73]], [[1lwu]] - Fba+Fbb+Fbg+peptide ligand – Sea lamprey<br /> | |
| - | + | [[1m1j]] - heFba+heFbb+heFbg+peptide ligand – hen<br /> | |
| - | [[3hus]], [[3h32]], [[3e1i]], [[3bvh]], [[2hlo]], [[2hod]], [[2hpc]], [[2oyh]], [[2oyi]], [[2h43]], [[2ffd]], [[1re3]], [[1rf1]], [[1n86]], [[1ltj]] | + | [[1ei3]] - heFba+heFbb+heFbg<br /> |
| - | <br /> | + | |
| - | hFba + hFbb + hFbg + thrombin + PPACK thrombin inhibitor | + | |
| - | [[ | + | |
| - | + | ||
| - | + | ||
| - | [[1jy3]], [[1deq]]<br /> | + | |
| - | cFba+cFbb+cFbg proteolytic fragment | + | |
| - | + | ||
| - | Fba + Fbb + Fbg + peptide ligand | + | |
| - | [[ | + | |
| - | + | ||
| - | heFba + heFbb + heFbg | + | |
| - | [[1ei3]] | + | |
| - | + | ||
| - | heFba + heFbb + heFbg | + | |
| - | + | ||
| - | ===Fibrinogen | + | ===Fibrinogen α chain=== |
| - | + | [[1fzd]] – hFba EC domain<br /> | |
| - | + | [[1bbr]] – hFba+cε-thrombin<br /> | |
| - | + | [[2jor]] – cFba – NMR<br /> | |
| + | [[2baf]] – cFba<br /> | ||
| - | ===Fibrinogen | + | ===Fibrinogen β chain=== |
| - | + | [[1fzf]], [[1fzg]] – hFb fragment double-D +peptide ligand<br /> | |
| - | hFb fragment double-D + peptide ligand | + | [[1fze]], [[1fza]], [[1fzb]] – hFb fragment D<br /> |
| - | ===Fibrinogen | + | ===Fibrinogen γ chain=== |
| + | |||
| + | [[2vr3]] – hFbg+SaClumping Factor A – ''Staphylococcus aureus''<br /> | ||
| + | [[2vdo]], [[2vdp]], [[2vdq]], [[2vdr]] – hFbg+Integrin alpha IIB+Integrin beta-3+Monoclonal antibody heavy and light chains<br /> | ||
| + | [[2fib]], 3fib - hFbg+peptide ligand<br /> | ||
| + | [[1fib]] – hFbg+Ca<br /> | ||
| + | [[1fic]], [[1fid]] – hFbg<br /> | ||
| + | [[1dug]] – Fbg C-terminal/glutathione S-transferase – ''Schistosoma japonicum''<br /> | ||
| + | [[2hwl]] – hFbg peptide+prothrombin<br /> | ||
| - | hFbg: [[1fic]], [[1fid]] <br /> | ||
| - | hFbg + Ca: [[1fib]]<br /> | ||
| - | hFbg + peptide ligand: [[2fib]], [[3fib]] <br /> | ||
| - | hFbg + SaClumping Factor A – ''Staphylococcus aureus'': [[2vr3]]<br /> | ||
| - | hFbg + Integrin alpha IIB + Integrin beta-3 + Monoclonal antibody heavy and light chains: [[2vdo]], [[2vdp]], [[2vdq]], [[2vdr]] <br /> | ||
==References== | ==References== | ||
Revision as of 12:44, 2 February 2011
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Fibrinogen is a glycoprotein found in the blood that is converted into fibrin during blood coagulation. Fibrinogen is cleaved by another protein, thrombin, exposing knobs A and B to form fibrin. [1] It is this fibrin that forms clots to prevent excessive bleeding from wounds sustained. Clotting factors, like factor XIII, are often linked to fibrin. [2]
Contents |
3D Structure of Fibrinogen
Fibrinogen is composed of 2 copies each of 3 non-identical chains alpha, beta, gamma (, , ).
Fibrinogen α+β+γ chains
3hus, 3h32, 3e1i, 3bvh, 2hlo, 2hod, 2hpc, 2oyh, 2oyi, 2h43, 2ffd, 1re3, 1rf1, 1n86, 1ltj – hFba+hFbb+hFbg+peptide ligand – human
3ghg, 2q9i, 2z4e - hFba+hFbb+hFbg+knob A & B
2a45 - hFba+hFbb+hFbg+thrombin+PPACK thrombin inhibitor
1re4, 1rf0, 1n8e, 1lt9 - hFba+hFbb+hFbg
1jy3, 1deq – cFba+cFbb+cFbg – cow
1jy2 - cFba+cFbb+cFbg proteolytic fragment
1n73, 1lwu - Fba+Fbb+Fbg+peptide ligand – Sea lamprey
1m1j - heFba+heFbb+heFbg+peptide ligand – hen
1ei3 - heFba+heFbb+heFbg
Fibrinogen α chain
1fzd – hFba EC domain
1bbr – hFba+cε-thrombin
2jor – cFba – NMR
2baf – cFba
Fibrinogen β chain
1fzf, 1fzg – hFb fragment double-D +peptide ligand
1fze, 1fza, 1fzb – hFb fragment D
Fibrinogen γ chain
2vr3 – hFbg+SaClumping Factor A – Staphylococcus aureus
2vdo, 2vdp, 2vdq, 2vdr – hFbg+Integrin alpha IIB+Integrin beta-3+Monoclonal antibody heavy and light chains
2fib, 3fib - hFbg+peptide ligand
1fib – hFbg+Ca
1fic, 1fid – hFbg
1dug – Fbg C-terminal/glutathione S-transferase – Schistosoma japonicum
2hwl – hFbg peptide+prothrombin
References
- ↑ Betts L, Merenbloom BK, Lord ST. The structure of fibrinogen fragment D with the 'A' knob peptide GPRVVE. J Thromb Haemost. 2006 May;4(5):1139-41. PMID:16689770 doi:10.1111/j.1538-7836.2006.01902.x
- ↑ Muszbek L, Bagoly Z, Bereczky Z, Katona E. The involvement of blood coagulation factor XIII in fibrinolysis and thrombosis. Cardiovasc Hematol Agents Med Chem. 2008 Jul;6(3):190-205. PMID:18673233
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