Heat Shock Proteins
From Proteopedia
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[[2v7z]] – rHsp70 NBD+sub – rat<br /> | [[2v7z]] – rHsp70 NBD+sub – rat<br /> | ||
[[7hsc]], [[1ckr]] - rHsp70 sub - NMR<br /> | [[7hsc]], [[1ckr]] - rHsp70 sub - NMR<br /> | ||
| + | [[3lca]] – yHsp70 Ssa1 C-terminal+yTOM71<br /> | ||
[[2v7y]] – Hsp70 NBD+sub – ''Geobacillus kaustophilus'' | [[2v7y]] – Hsp70 NBD+sub – ''Geobacillus kaustophilus'' | ||
=== Hsp90 – 4 domains: N-terminus (NTD); linker; middle (MD); C-terminus (CT) === | === Hsp90 – 4 domains: N-terminus (NTD); linker; middle (MD); C-terminus (CT) === | ||
| - | [[3k97]], [[3hek]] – hHsp90 NTD+pyrrolidin derivative – human<br /> | + | [[3k97]], [[3hek]], [[3mnq]] – hHsp90 NTD+pyrrolidin derivative – human<br /> |
[[3k98]], [[3k99]] - hHsp90 NTD+indole derivative<br /> | [[3k98]], [[3k99]] - hHsp90 NTD+indole derivative<br /> | ||
[[2wi1]], [[2wi2]], [[2wi3]], [[2wi4]], [[2wi5]], [[2wi6]], [[2wi7]] - hHsp90 NTD+2-amino thienopyrimidine<br /> | [[2wi1]], [[2wi2]], [[2wi3]], [[2wi4]], [[2wi5]], [[2wi6]], [[2wi7]] - hHsp90 NTD+2-amino thienopyrimidine<br /> | ||
Revision as of 13:39, 2 February 2011
Heat Shock Proteins (Hsp). The Hsp are proteins which are expressed when cells are exposed to stresses like heat. Hsp60, Hsp70, Hsp90 etc. are named according to their molecular weights. Their function is to provide protection from stress. The images at the left and at the right correspond to one representative Hsp, i.e. the crystal structure of Hsp60 from Methanococcus maripaludis (3los).
3D Structures of Heat Shock Proteins
Small Hsp
1shs – Hsp – Methanococcus jannaschii
1gme – Hsp 17kD – wheat
2bol – Hsp – Taenia saginata
2h50, 2h53 – yHsp26 – yeast
2wj5 – rHsp20 crystallin domain – rat
2wj7, 3l1g – hHspB crystallin domain – human
3bbu – EcHsp15 - Escherichia coli – Cryo-EM
1ons – EcHsp31
3gla – Hsp – Xanthomonas axonopodis
Hsp33
1hw7 – EcHsp33 N-terminal
1i7f – EcHsp33 chaperone domain (mutant)
1xjh - EcHsp33 C-terminal - NMR
1vq0 – Hsp33 – Thermotoga maritime
1vzy – Hsp33 – Bacillus subtilis
HslV, HslU, HslJ
1e94, 1yyf – EcHslV+HslU
2kts – EcHslJ - NMR
1g41 – HiHslU – Haemophilus influenza
1im2 – HiHslU NBD
Hsp40
1c3g – yHsp40 C-terminal peptide binding domain
2qld – hHsp40
Hsp60 - the large subunit of the chaperonin molecule GroEL
3los – MmHsp60 - GroEL – Methanococcus maripaludis – closed state
3iyf - MmHsp60 - GroEL – open state
3e76 – EcHsp60 – GroEL+Tl ion – Escherichia coli
2nwc, 1oel, 1grl, 1la1 - EcHsp60 – GroEL
2eu1 - EcHsp60 (mutant) – GroEL
2cgt - EcHsp60 – GroEL+ADP+capsid assembly protein Gp31
2c7c, 2c7d - EcHsp60 – GroEL+GroES – cryo EM
1we3, 1wf4 - TtHsp60 – GroEL+GroES – Thermus thermophilus
1gr5 - EcHsp60 – GroEL – cryo EM
1gru - EcHsp60 – GroEL+ATP+GroES+ADP – cryo EM
1dkd - EcHsp60 – GroEL apical (top) domain (146 amino acids)+12-mer peptide
1dk7, 1jon - EcHsp60 – GroEL apical domain
1srv - TtHsp60 – GroEL apical domain
1ass, 1asx - Hsp60 – GroEL apical domain – Thermoplasma acidophilum
1kid - EcHsp60 (mutant) – GroEL apical domain
Hsp70 – 3 domains: N-terminus ATPase hydrolyzes ATP to ADP (NBD); hydrophobic amino acid binding domain (sub): C-terminus lid domain (lid).
3a8y – hHsp70 NBD+BAG domain regulator protein – human
3fzf - hHsp70 NBD+BAG domain regulator protein+ATP
3fzh, 3fzm - hHsp70 NBD+BAG domain regulator protein+ adenosine derivative
3fzk, 3fzl - hHsp70 NBD+BAG domain regulator protein+ purine derivative
3cqx - Hsp70 NBD+BAG domain regulator protein – mouse
3lof – hHsp70 lid
2p32 - CeHsp70 lid
3l6q - CpHsp70 NBD – Cryptosporidium parvum
3kvg - CpHsp70 NBD+AMPPNP
3l4i - CpHsp70 NBD+ADP+P
3jxu, 3i33, 3gdq, 3fe1 - hHsp70 NBD+ADP+P
3iuc - hHsp70 NBD+ADP
2e88, 1s3x, 1hjo - hHsp70 NBD
2e8a - hHsp70 NBD+AMPPNP
2qw9 – cHsp70 NBD – cow
2bup, 1bup, 1qqm, 1qqn - cHsp70 NBD (mutant)
2qwl, 2qwm - cHsp70 NBD+ADP
1qqo – cHsp70 (mutant)
2qwn, 2qwo, 2qwp, 2qwq, 2qwr - cHsp70 NBD (mutant)+ auxilin protein
2kho – EcHsp70 – Escherichia coli – NMR
1q5l - EcHsp70 sub domain+peptide - NMR
3gl1 - ScHsp70 NBD – Saccharomyces cerevisiae
3dpo – EcHsp70 sub+12-mer peptide
3dpp, 3dpq – EcHsp70 sub+20-mer peptide
3dob, 3dqg, 2op6 - CeHsp70 sub – Caenoharbditis elegans
2d2e, 3d2f – ScHsp70 NBD+SSE1(Hsp110)
2v7z – rHsp70 NBD+sub – rat
7hsc, 1ckr - rHsp70 sub - NMR
3lca – yHsp70 Ssa1 C-terminal+yTOM71
2v7y – Hsp70 NBD+sub – Geobacillus kaustophilus
Hsp90 – 4 domains: N-terminus (NTD); linker; middle (MD); C-terminus (CT)
3k97, 3hek, 3mnq – hHsp90 NTD+pyrrolidin derivative – human
3k98, 3k99 - hHsp90 NTD+indole derivative
2wi1, 2wi2, 2wi3, 2wi4, 2wi5, 2wi6, 2wi7 - hHsp90 NTD+2-amino thienopyrimidine
3hhu - hHsp90 NTD+ carbamic acid derivative
3ft8, 3ft5 - hHsp90 NTD+quinazoline derivative
2k5b - hHsp90 NTD+Cdc37 – NMR - docking
3eko, 3ekr - hHsp90 NTD+dihydroxyphenyl amide
2jjc - hHsp90 NTD+pyrimidine-2-amine
3bm9, 3bmy - hHsp90 NTD+benzisoxazole
2of6 - hHsp90 NTD+triazine derivative
2qfo - hHsp90 NTD+pyrimidine derivative
1uy6, 1uy7, 1uy8, 1uy9, 1uyc, 1uyd, 1uye, 1uyf, 1uyg, 1uyh, 1uyi, 1uyk, 1uyl - hHsp90 NTD+purine derivative
2qg0, 2bz5 - hHsp90 NTD+sulfonamide derivative
2qg2, 2cvi, 2cvj, 2uwd - hHsp90 NTD+oxazol derivative
3d0b - hHsp90 NTD+benzamide derivative
3inw, 3inx - hHsp90 NTD+pochoxime derivative
2fwy, 2fwz, 2h55, 1uym - hHsp90 NTD+PU inhibitor
2ccs, 2cct, 2ccu, 2cdd, 2byh, 2byi, 2bsm, 2bt0, 1yc3, 1yc1, 1yc4 - hHsp90 NTD+pyrazol derivative
1byq - hHsp90 NTD+ATP-Mg
2qf6 - hHsp90 + antigen
2xhr, 2xht, 2xhx, 2xjg, 2xjj, 2xjx, 2xk2, 2xdx, 2xdu, 2xds, 2xdl, 2xdk, 2xab, 2vcj, 2vci, 3hyy, 3hyz, 3hz1, 3hz5, 3mnr - hHsp90 NTD+ antigen
3pry – hHsp90 MD
2brc, 2bre, 1am1 - yHsp90 NTD+pyrazol derivative
1amw - yHsp90 NTD+ADP
1ah6, 1ah8 - yHsp90 NTD
1osf, 1yer, 1yes, 1yet - hHsp90 NTD+geldamycin
1bgq – yHsp90+radicicol
1a4h, 2weq – yHsp90+ geldamycin
3ied - PfHsp90 NTD+AMPPN – Plasmodium falciparum
3k60 - PfHsp90 NTD+ADP
2jki - Hsp90 NTD+SGT1 domain protein – barley
1sf8 – EcHsp90 C-terminal
1y4s, 1y4u, 2iop, 2ior - EcHsp90+ADP
2gq0 - EcHsp90 MD
2ioq - EcHsp90
2h8m, 2hch – dHsp90 NTD – dog
2o1w - dHsp90 NTD+MD
2hg1 - dHsp90 NTD+ligand
2o1t – dHsp90 MD+CT
2o1u – dHsp90+AMPPNP
2o1v - dHsp90+ADP
2xcm – Hsp90 NTD+CGT1+RAR1 – Hordum vulgare
3h80 – LmHsp90 NTD – Leishmania major
3hjc - LmHsp90 CT
3o6o, 3omu, 3opd – TbHsp90 N-terminal+inhibitor – Trypanosoma brucei
Hsp82 is the yeast equivalent of Hsp90 in mammals
1ah6, 1ah8 – yHsp82 NTD1ah6, 1ah8 – yHsp82 NTD
2xd6 - yHsp82 NTD+macrolactone
2wep – yHsp82 NTD (mutant)+ADP
2akp - yHsp82 NTD (mutant)
1weq, 3c11 - yHsp82 NTD (mutant)+ geldamycin
2wer - yHsp82 NTD (mutant)+radicicol
1bgq - yHsp82 NTD +radicicol
2iws, 2iwu, 2iwx, 2cgf - yHsp82 NTD +radicicol analogues
2vw5, 2vwc - yHsp82 NTD +7-o-carbamoylpremacbecin
3c0e - yHsp82 NTD (mutant)
2fxs - yHsp82 NTD +radamide
1zw9 - yHsp82 NTD + adenine derivative
1zwh - yHsp82 NTD + radester amine
2brc, 2bre - yHsp82 NTD+pyrazol derivative
2cg9 – yHsp82+co-chaperone SBA1
2cge - yHsp82 MD+CT+co-chaperone SBA1
1hk7 - yHsp82 MD
1usu, 1usv - yHsp82 MD+co-chaperone AHA1
1us7 - yHsp82 NTD+co-chaperone cdc37
3fp2 – yHsp82 CT+TOM71
Hsp100 are named ClpA or ClpB
1r6b, 1ksf – EcClpA (mutant) - Escherichia coli
1khy – EcClpB NTD
1jbk – EcClpB NBD
1k6k - EcClpA NTD
Hsp110 in mammals is named Sse1, Sse2 in yeast
3d2e, 3d2f, 3c7n – Sse1+Hsp70 – yeast
2qxl – Sse1 - yeast
