2g70

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[[Image:2g70.png|left|200px]]
[[Image:2g70.png|left|200px]]
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{{STRUCTURE_2g70| PDB=2g70 | SCENE= }}
{{STRUCTURE_2g70| PDB=2g70 | SCENE= }}
===Structure of human PNMT in complex with inhibitor 3-hydroxymethyl-7-nitro-THIQ and AdoMet (SAM)===
===Structure of human PNMT in complex with inhibitor 3-hydroxymethyl-7-nitro-THIQ and AdoMet (SAM)===
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{{ABSTRACT_PUBMED_17845018}}
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==See Also==
==See Also==
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*[[Phenylethanolamine N-methyltransferase]]
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*[[Phenylethanolamine N-methyltransferase|Phenylethanolamine N-methyltransferase]]
==Reference==
==Reference==
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<ref group="xtra">PMID:17845018</ref><references group="xtra"/>
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<ref group="xtra">PMID:017845018</ref><ref group="xtra">PMID:016710295</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Phenylethanolamine N-methyltransferase]]
[[Category: Phenylethanolamine N-methyltransferase]]
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[[Category: Tyndall, J D.A.]]
[[Category: Tyndall, J D.A.]]
[[Category: Methyltransferase]]
[[Category: Methyltransferase]]
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[[Category: Transferase]]

Revision as of 17:03, 25 July 2012

Template:STRUCTURE 2g70

Contents

Structure of human PNMT in complex with inhibitor 3-hydroxymethyl-7-nitro-THIQ and AdoMet (SAM)

Template:ABSTRACT PUBMED 17845018

About this Structure

2g70 is a 2 chain structure of Phenylethanolamine N-methyltransferase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Gee CL, Drinkwater N, Tyndall JD, Grunewald GL, Wu Q, McLeish MJ, Martin JL. Enzyme adaptation to inhibitor binding: a cryptic binding site in phenylethanolamine N-methyltransferase. J Med Chem. 2007 Oct 4;50(20):4845-53. Epub 2007 Sep 11. PMID:17845018 doi:10.1021/jm0703385
  • Lu J, Edwards RA, Wong JJ, Manchak J, Scott PG, Frost LS, Glover JN. Protonation-mediated structural flexibility in the F conjugation regulatory protein, TraM. EMBO J. 2006 Jun 21;25(12):2930-9. Epub 2006 May 18. PMID:16710295

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