3c1k
From Proteopedia
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{{STRUCTURE_3c1k| PDB=3c1k | SCENE= }} | {{STRUCTURE_3c1k| PDB=3c1k | SCENE= }} | ||
===Crystal structure of thrombin in complex with inhibitor 15=== | ===Crystal structure of thrombin in complex with inhibitor 15=== | ||
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{{ABSTRACT_PUBMED_18291642}} | {{ABSTRACT_PUBMED_18291642}} | ||
==About this Structure== | ==About this Structure== | ||
| - | [[3c1k]] is a 2 chain structure of [[Hirudin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C1K OCA]. | + | [[3c1k]] is a 2 chain structure of [[Hirudin]] and [[Thrombin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C1K OCA]. |
==See Also== | ==See Also== | ||
| - | *[[Hirudin]] | + | *[[Hirudin|Hirudin]] |
| + | *[[Thrombin|Thrombin]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:018291642</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Thrombin]] | [[Category: Thrombin]] | ||
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[[Category: Acute phase]] | [[Category: Acute phase]] | ||
[[Category: Blood coagulation]] | [[Category: Blood coagulation]] | ||
| - | [[Category: Calcium]] | ||
[[Category: Cleavage on pair of basic residue]] | [[Category: Cleavage on pair of basic residue]] | ||
[[Category: Disease mutation]] | [[Category: Disease mutation]] | ||
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[[Category: Glycoprotein]] | [[Category: Glycoprotein]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
| + | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
[[Category: Kringle]] | [[Category: Kringle]] | ||
| - | [[Category: Pharmaceutical]] | ||
| - | [[Category: Polymorphism]] | ||
[[Category: Protease]] | [[Category: Protease]] | ||
[[Category: Protease inhibitor]] | [[Category: Protease inhibitor]] | ||
Revision as of 04:58, 27 July 2012
Contents |
Crystal structure of thrombin in complex with inhibitor 15
Template:ABSTRACT PUBMED 18291642
About this Structure
3c1k is a 2 chain structure of Hirudin and Thrombin with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Isaacs RC, Solinsky MG, Cutrona KJ, Newton CL, Naylor-Olsen AM, McMasters DR, Krueger JA, Lewis SD, Lucas BJ, Kuo LC, Yan Y, Lynch JJ, Lyle EA. Structure-based design of novel groups for use in the P1 position of thrombin inhibitor scaffolds. Part 2: N-acetamidoimidazoles. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2062-6. Epub 2008 Jan 30. PMID:18291642 doi:10.1016/j.bmcl.2008.01.098
Categories: Homo sapiens | Thrombin | Yan, Y. | Acute phase | Blood coagulation | Cleavage on pair of basic residue | Disease mutation | Gamma-carboxyglutamic acid | Glycoprotein | Hydrolase | Hydrolase-hydrolase inhibitor complex | Kringle | Protease | Protease inhibitor | Secreted | Serine protease | Serine protease inhibitor | Sulfation | Thrombin inhibitor complex | Zymogen
