2j4x
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
| - | 2J4X is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_dysgalactiae Streptococcus dysgalactiae] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Gol Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J4X OCA]. | + | 2J4X is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_dysgalactiae Streptococcus dysgalactiae] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Gol+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J4X OCA]. |
==Reference== | ==Reference== | ||
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[[Category: signaling protein]] | [[Category: signaling protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 10:41:36 2008'' |
Revision as of 08:41, 3 February 2008
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STREPTOCOCCUS DYSGALACTIAE-DERIVED MITOGEN (SDM)
Overview
Bacterial superantigens are protein toxins with an ability to cause, serious diseases in humans by activating a large number of T cells., Streptococcus dysgalactiae-derived mitogen (SDM) is a novel superantigen, that is distinct from other known superantigens based on phylogenetic, analysis. The X-ray structure of SDM has been determined at 1.95 A, resolution. SDM shares the same characteristic fold with other, superantigens, but it shows a major structural difference due to the lack, of the alpha5 helix between the beta10 and beta11 strands. A bound zinc, ion was identified in the structure at the C-terminal domain of the, molecule. SDM appears to bind to the major histocompatibility complex, class II beta-chain through the zinc-binding site, as described by, mutagenesis data and structural comparisons. T-cell binding instead shows, a significant difference compared to other superantigens. The mutation of, Asn11 (a conserved residue that is known to be significant for, T-cell-receptor binding in other superantigens) and Lys15 to Ala did not, cause any decrease in the mitogenic activity of SDM. This observation and, the lack of the alpha5 helix suggest alterations in T-cell-receptor, binding.
About this Structure
2J4X is a Single protein structure of sequence from Streptococcus dysgalactiae with and as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Crystal Structure of Streptococcus dysgalactiae-Derived Mitogen Reveals a Zinc-Binding Site and Alterations in TcR Binding., Saarinen S, Kato H, Uchiyama T, Miyoshi-Akiyama T, Papageorgiou AC, J Mol Biol. 2007 Nov 9;373(5):1089-97. Epub 2007 Aug 21. PMID:17900619
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