1h8d
From Proteopedia
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{{STRUCTURE_1h8d| PDB=1h8d | SCENE= }} | {{STRUCTURE_1h8d| PDB=1h8d | SCENE= }} | ||
===X-RAY STRUCTURE OF THE HUMAN ALPHA-THROMBIN COMPLEX WITH A TRIPEPTIDE PHOSPHONATE INHIBITOR.=== | ===X-RAY STRUCTURE OF THE HUMAN ALPHA-THROMBIN COMPLEX WITH A TRIPEPTIDE PHOSPHONATE INHIBITOR.=== | ||
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| - | (as it appears on PubMed at http://www.pubmed.gov), where 11493008 is the PubMed ID number. | ||
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{{ABSTRACT_PUBMED_11493008}} | {{ABSTRACT_PUBMED_11493008}} | ||
==About this Structure== | ==About this Structure== | ||
| - | [[1h8d]] is a 3 chain structure of [[Hirudin]] with sequence from [http://en.wikipedia.org/wiki/Hirudo_medicinalis Hirudo medicinalis] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H8D OCA]. | + | [[1h8d]] is a 3 chain structure of [[Hirudin]] and [[Thrombin]] with sequence from [http://en.wikipedia.org/wiki/Hirudo_medicinalis Hirudo medicinalis] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H8D OCA]. |
==See Also== | ==See Also== | ||
| - | *[[Hirudin]] | + | *[[Hirudin|Hirudin]] |
| + | *[[Thrombin|Thrombin]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:011493008</ref><ref group="xtra">PMID:008605148</ref><references group="xtra"/> |
[[Category: Hirudo medicinalis]] | [[Category: Hirudo medicinalis]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
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[[Category: Green, D S.]] | [[Category: Green, D S.]] | ||
[[Category: Skordalakes, E.]] | [[Category: Skordalakes, E.]] | ||
| + | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
[[Category: Serine protease]] | [[Category: Serine protease]] | ||
Revision as of 02:28, 26 July 2012
Contents |
X-RAY STRUCTURE OF THE HUMAN ALPHA-THROMBIN COMPLEX WITH A TRIPEPTIDE PHOSPHONATE INHIBITOR.
Template:ABSTRACT PUBMED 11493008
About this Structure
1h8d is a 3 chain structure of Hirudin and Thrombin with sequence from Hirudo medicinalis and Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Skordalakes E, Dodson GG, Green DS, Goodwin CA, Scully MF, Hudson HR, Kakkar VV, Deadman JJ. Inhibition of human alpha-thrombin by a phosphonate tripeptide proceeds via a metastable pentacoordinated phosphorus intermediate. J Mol Biol. 2001 Aug 17;311(3):549-55. PMID:11493008 doi:10.1006/jmbi.2001.4872
- Bertrand JA, Oleksyszyn J, Kam CM, Boduszek B, Presnell S, Plaskon RR, Suddath FL, Powers JC, Williams LD. Inhibition of trypsin and thrombin by amino(4-amidinophenyl)methanephosphonate diphenyl ester derivatives: X-ray structures and molecular models. Biochemistry. 1996 Mar 12;35(10):3147-55. PMID:8605148 doi:http://dx.doi.org/10.1021/bi9520996
