1z77
From Proteopedia
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==Overview== | ==Overview== | ||
| - | The crystal structure of a putative transcriptional regulator protein | + | The crystal structure of a putative transcriptional regulator protein TM1030 from Thermotoga maritima, a hyperthermophilic bacterium, was determined by an unusual multi-wavelength anomalous dispersion method at 2.0 A resolution, in which data from two different crystals and two different beamlines were used. The protein belongs to the tetracycline repressor TetR superfamily. The three-dimensional structure of TM1030 is similar to the structures of proteins that function as multidrug-binding transcriptional repressors, and contains a large solvent-exposed pocket similar to the drug-binding pockets present in those repressors. The asymmetric unit in the crystal structure contains a single protein chain and the twofold symmetry of the dimer is adopted by the crystal symmetry. The structure described in this paper is an apo- form of TM1030. Although it is known that the protein is significantly overexpressed during heat shock, its detailed function cannot be yet explained. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Chruszcz, M.]] | [[Category: Chruszcz, M.]] | ||
[[Category: Cymborowski, M.]] | [[Category: Cymborowski, M.]] | ||
| - | [[Category: Koclega, K | + | [[Category: Koclega, K D.]] |
[[Category: Kudritska, M.]] | [[Category: Kudritska, M.]] | ||
| - | [[Category: MCSG, Midwest | + | [[Category: MCSG, Midwest Center for Structural Genomics.]] |
[[Category: Minor, W.]] | [[Category: Minor, W.]] | ||
| - | [[Category: Zimmerman, M | + | [[Category: Zimmerman, M D.]] |
[[Category: EDO]] | [[Category: EDO]] | ||
[[Category: mcsg]] | [[Category: mcsg]] | ||
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[[Category: transcriptional regulator]] | [[Category: transcriptional regulator]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:12:52 2008'' |
Revision as of 14:13, 21 February 2008
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Crystal structure of transcriptional regulator protein from Thermotoga maritima.
Overview
The crystal structure of a putative transcriptional regulator protein TM1030 from Thermotoga maritima, a hyperthermophilic bacterium, was determined by an unusual multi-wavelength anomalous dispersion method at 2.0 A resolution, in which data from two different crystals and two different beamlines were used. The protein belongs to the tetracycline repressor TetR superfamily. The three-dimensional structure of TM1030 is similar to the structures of proteins that function as multidrug-binding transcriptional repressors, and contains a large solvent-exposed pocket similar to the drug-binding pockets present in those repressors. The asymmetric unit in the crystal structure contains a single protein chain and the twofold symmetry of the dimer is adopted by the crystal symmetry. The structure described in this paper is an apo- form of TM1030. Although it is known that the protein is significantly overexpressed during heat shock, its detailed function cannot be yet explained.
About this Structure
1Z77 is a Single protein structure of sequence from Thermotoga maritima with as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of a transcriptional regulator TM1030 from Thermotoga maritima solved by an unusual MAD experiment., Koclega KD, Chruszcz M, Zimmerman MD, Cymborowski M, Evdokimova E, Minor W, J Struct Biol. 2007 Sep;159(3):424-32. Epub 2007 May 16. PMID:17588774
Page seeded by OCA on Thu Feb 21 16:12:52 2008
Categories: Single protein | Thermotoga maritima | Chruszcz, M. | Cymborowski, M. | Koclega, K D. | Kudritska, M. | MCSG, Midwest Center for Structural Genomics. | Minor, W. | Zimmerman, M D. | EDO | Mcsg | Midwest center for structural genomics | Protein structure initiative | Psi | Structural genomics | Tetr family | Transcriptional regulator
