1gj4
From Proteopedia
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[[Image:1gj4.png|left|200px]] | [[Image:1gj4.png|left|200px]] | ||
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{{STRUCTURE_1gj4| PDB=1gj4 | SCENE= }} | {{STRUCTURE_1gj4| PDB=1gj4 | SCENE= }} | ||
===SELECTIVITY AT S1, H2O DISPLACEMENT, UPA, TPA, SER190/ALA190 PROTEASE, STRUCTURE-BASED DRUG DESIGN=== | ===SELECTIVITY AT S1, H2O DISPLACEMENT, UPA, TPA, SER190/ALA190 PROTEASE, STRUCTURE-BASED DRUG DESIGN=== | ||
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{{ABSTRACT_PUBMED_11731301}} | {{ABSTRACT_PUBMED_11731301}} | ||
==About this Structure== | ==About this Structure== | ||
| - | [[1gj4]] is a 3 chain structure of [[Hirudin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GJ4 OCA]. | + | [[1gj4]] is a 3 chain structure of [[Hirudin]] and [[Thrombin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GJ4 OCA]. |
==See Also== | ==See Also== | ||
| - | *[[Hirudin]] | + | *[[Hirudin|Hirudin]] |
| + | *[[Thrombin|Thrombin]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:011731301</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Thrombin]] | [[Category: Thrombin]] | ||
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[[Category: Blood clotting]] | [[Category: Blood clotting]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
| + | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
[[Category: Oxyanion hole water]] | [[Category: Oxyanion hole water]] | ||
[[Category: Shift of pka of his57]] | [[Category: Shift of pka of his57]] | ||
Revision as of 10:30, 26 July 2012
Contents |
SELECTIVITY AT S1, H2O DISPLACEMENT, UPA, TPA, SER190/ALA190 PROTEASE, STRUCTURE-BASED DRUG DESIGN
Template:ABSTRACT PUBMED 11731301
About this Structure
1gj4 is a 3 chain structure of Hirudin and Thrombin with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Katz BA, Sprengeler PA, Luong C, Verner E, Elrod K, Kirtley M, Janc J, Spencer JR, Breitenbucher JG, Hui H, McGee D, Allen D, Martelli A, Mackman RL. Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targets. Chem Biol. 2001 Nov;8(11):1107-21. PMID:11731301
Categories: Homo sapiens | Thrombin | Allen, D. | Breitenbucher, J G. | Hui, H. | Katz, B A. | Luong, C. | Mackman, R L. | Martelli, A. | McGee, D. | Spencer, J R. | Sprengeler, P A. | Verner, E. | Blood clotting | Hydrolase | Hydrolase-hydrolase inhibitor complex | Oxyanion hole water | Shift of pka of his57 | Specificity | Structure-based drug design | Three-centered | Trypsin | Urokinase | Very short hydrogen bond | Zn+2-mediated inhibition
