1tmb
From Proteopedia
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{{STRUCTURE_1tmb| PDB=1tmb | SCENE= }} | {{STRUCTURE_1tmb| PDB=1tmb | SCENE= }} | ||
===MOLECULAR BASIS FOR THE INHIBITION OF HUMAN ALPHA-THROMBIN BY THE MACROCYCLIC PEPTIDE CYCLOTHEONAMIDE A=== | ===MOLECULAR BASIS FOR THE INHIBITION OF HUMAN ALPHA-THROMBIN BY THE MACROCYCLIC PEPTIDE CYCLOTHEONAMIDE A=== | ||
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{{ABSTRACT_PUBMED_8367461}} | {{ABSTRACT_PUBMED_8367461}} | ||
==About this Structure== | ==About this Structure== | ||
| - | [[1tmb]] is a 4 chain structure of [[Hirudin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TMB OCA]. | + | [[1tmb]] is a 4 chain structure of [[Hirudin]] and [[Thrombin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Theonella_sp. Theonella sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TMB OCA]. |
==See Also== | ==See Also== | ||
| - | *[[Hirudin]] | + | *[[Hirudin|Hirudin]] |
| + | *[[Thrombin|Thrombin]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:008367461</ref><ref group="xtra">PMID:008732754</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| + | [[Category: Theonella sp.]] | ||
[[Category: Thrombin]] | [[Category: Thrombin]] | ||
[[Category: Maryanoff, B E.]] | [[Category: Maryanoff, B E.]] | ||
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[[Category: Qiu, X.]] | [[Category: Qiu, X.]] | ||
[[Category: Tulinsky, A.]] | [[Category: Tulinsky, A.]] | ||
| + | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
| + | [[Category: Serine proteinase]] | ||
Revision as of 03:43, 26 July 2012
Contents |
MOLECULAR BASIS FOR THE INHIBITION OF HUMAN ALPHA-THROMBIN BY THE MACROCYCLIC PEPTIDE CYCLOTHEONAMIDE A
Template:ABSTRACT PUBMED 8367461
About this Structure
1tmb is a 4 chain structure of Hirudin and Thrombin with sequence from Homo sapiens and Theonella sp.. Full crystallographic information is available from OCA.
See Also
Reference
- Maryanoff BE, Qiu X, Padmanabhan KP, Tulinsky A, Almond HR Jr, Andrade-Gordon P, Greco MN, Kauffman JA, Nicolaou KC, Liu A, et al.. Molecular basis for the inhibition of human alpha-thrombin by the macrocyclic peptide cyclotheonamide A. Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):8048-52. PMID:8367461
- Ganesh V, Lee AY, Clardy J, Tulinsky A. Comparison of the structures of the cyclotheonamide A complexes of human alpha-thrombin and bovine beta-trypsin. Protein Sci. 1996 May;5(5):825-35. PMID:8732754 doi:10.1002/pro.5560050504
