2r2m
From Proteopedia
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[[Image:2r2m.png|left|200px]] | [[Image:2r2m.png|left|200px]] | ||
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{{STRUCTURE_2r2m| PDB=2r2m | SCENE= }} | {{STRUCTURE_2r2m| PDB=2r2m | SCENE= }} | ||
===2-(2-Chloro-6-Fluorophenyl)Acetamides as Potent Thrombin Inhibitors=== | ===2-(2-Chloro-6-Fluorophenyl)Acetamides as Potent Thrombin Inhibitors=== | ||
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{{ABSTRACT_PUBMED_17889527}} | {{ABSTRACT_PUBMED_17889527}} | ||
==About this Structure== | ==About this Structure== | ||
| - | [[2r2m]] is a 3 chain structure of [[Hirudin]] with sequence from [http://en.wikipedia.org/wiki/Hirudo_medicinalis Hirudo medicinalis] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R2M OCA]. | + | [[2r2m]] is a 3 chain structure of [[Hirudin]] and [[Thrombin]] with sequence from [http://en.wikipedia.org/wiki/Hirudo_medicinalis Hirudo medicinalis] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R2M OCA]. |
==See Also== | ==See Also== | ||
| - | *[[Hirudin]] | + | *[[Hirudin|Hirudin]] |
| + | *[[Thrombin|Thrombin]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:017889527</ref><references group="xtra"/> |
[[Category: Hirudo medicinalis]] | [[Category: Hirudo medicinalis]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
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[[Category: Acute phase]] | [[Category: Acute phase]] | ||
[[Category: Blood coagulation]] | [[Category: Blood coagulation]] | ||
| - | [[Category: Calcium]] | ||
[[Category: Cleavage on pair of basic residue]] | [[Category: Cleavage on pair of basic residue]] | ||
[[Category: Disease mutation]] | [[Category: Disease mutation]] | ||
[[Category: Gamma-carboxyglutamic acid]] | [[Category: Gamma-carboxyglutamic acid]] | ||
[[Category: Glycoprotein]] | [[Category: Glycoprotein]] | ||
| - | [[Category: Hydrolase]] | + | [[Category: Hydrolase-hydrolase inhibitor complex]] |
[[Category: Kringle]] | [[Category: Kringle]] | ||
| - | [[Category: Polymorphism]] | ||
[[Category: Protease]] | [[Category: Protease]] | ||
[[Category: Protease inhibitor]] | [[Category: Protease inhibitor]] | ||
Revision as of 18:33, 26 July 2012
Contents |
2-(2-Chloro-6-Fluorophenyl)Acetamides as Potent Thrombin Inhibitors
Template:ABSTRACT PUBMED 17889527
About this Structure
2r2m is a 3 chain structure of Hirudin and Thrombin with sequence from Hirudo medicinalis and Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Lee L, Kreutter KD, Pan W, Crysler C, Spurlino J, Player MR, Tomczuk B, Lu T. 2-(2-Chloro-6-fluorophenyl)acetamides as potent thrombin inhibitors. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6266-9. Epub 2007 Sep 8. PMID:17889527 doi:10.1016/j.bmcl.2007.09.013
Categories: Hirudo medicinalis | Homo sapiens | Thrombin | Spurlino, J. | Acute phase | Blood coagulation | Cleavage on pair of basic residue | Disease mutation | Gamma-carboxyglutamic acid | Glycoprotein | Hydrolase-hydrolase inhibitor complex | Kringle | Protease | Protease inhibitor | Secreted | Serine protease | Serine protease inhibitor | Sulfation | Zymogen
