1gcn
From Proteopedia
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===X-RAY ANALYSIS OF GLUCAGON AND ITS RELATIONSHIP TO RECEPTOR BINDING=== | ===X-RAY ANALYSIS OF GLUCAGON AND ITS RELATIONSHIP TO RECEPTOR BINDING=== | ||
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{{ABSTRACT_PUBMED_171582}} | {{ABSTRACT_PUBMED_171582}} | ||
==About this Structure== | ==About this Structure== | ||
| - | [[1gcn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GCN OCA]. | + | [[1gcn]] is a 1 chain structure of [[Glucagon]] with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GCN OCA]. |
==See Also== | ==See Also== | ||
| - | *[[ | + | *[[Glucagon|Glucagon]] |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:000171582</ref><ref group="xtra">PMID:019597507</ref><references group="xtra"/> |
[[Category: Sus scrofa]] | [[Category: Sus scrofa]] | ||
[[Category: Blundell, T L.]] | [[Category: Blundell, T L.]] | ||
Revision as of 19:45, 26 July 2012
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| 1gcn, resolution 3.00Å () | |||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Contents |
X-RAY ANALYSIS OF GLUCAGON AND ITS RELATIONSHIP TO RECEPTOR BINDING
X-ray analysis of the pancreatic hormone glucagon shows that in crystals the polypeptide adopts a mainly helical conformation, which is stabilised by hydrophobic interactions between molecules related by threefold symmetry. A model is presented in which the glucagon molecule exists in dilute solutions as an equilibrium population of conformers with little retention of conformers with little retention of structure, and in which the helical conformation is stablised by hydrophobic interactions either as an oligomer or as a complex with the receptor.
X-ray analysis of glucagon and its relationship to receptor binding., Sasaki K, Dockerill S, Adamiak DA, Tickle IJ, Blundell T, Nature. 1975 Oct 30;257(5529):751-7. PMID:171582
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1gcn is a 1 chain structure of Glucagon with sequence from Sus scrofa. Full crystallographic information is available from OCA.
See Also
Reference
- Sasaki K, Dockerill S, Adamiak DA, Tickle IJ, Blundell T. X-ray analysis of glucagon and its relationship to receptor binding. Nature. 1975 Oct 30;257(5529):751-7. PMID:171582
- Day JW, Ottaway N, Patterson JT, Gelfanov V, Smiley D, Gidda J, Findeisen H, Bruemmer D, Drucker DJ, Chaudhary N, Holland J, Hembree J, Abplanalp W, Grant E, Ruehl J, Wilson H, Kirchner H, Lockie SH, Hofmann S, Woods SC, Nogueiras R, Pfluger PT, Perez-Tilve D, DiMarchi R, Tschop MH. A new glucagon and GLP-1 co-agonist eliminates obesity in rodents. Nat Chem Biol. 2009 Oct;5(10):749-57. Epub 2009 Jul 13. PMID:19597507 doi:10.1038/nchembio.209
