1x70

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Revision as of 13:14, 28 December 2010

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spinqualitylabelsall models PDB ID 1x70 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1x70, resolution 2.10Å ()
Ligands:	, , ,
Gene:	DPP4, ADCP2, CD26 (Homo sapiens)
Activity:	Dipeptidyl-peptidase IV, with EC number 3.4.14.5
Structural annotation: Resources: CATH : 1X70A01, 1X70A02, 1X70B02, 1X70B01 InterPro : Ipr002469, Ipr002471, Ipr001375 Pfam : PF00930, PF00326 SCOP : d1x70a2, d1x70a1, d1x70b2, d1x70b1
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Contents 1 HUMAN DIPEPTIDYL PEPTIDASE IV IN COMPLEX WITH A BETA AMINO ACID INHIBITOR 2 About this Structure 3 See Also 4 Reference

HUMAN DIPEPTIDYL PEPTIDASE IV IN COMPLEX WITH A BETA AMINO ACID INHIBITOR

Template:ABSTRACT PUBMED 15634008

About this Structure

1x70 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Sitagliptin

Reference

• Kim D, Wang L, Beconi M, Eiermann GJ, Fisher MH, He H, Hickey GJ, Kowalchick JE, Leiting B, Lyons K, Marsilio F, McCann ME, Patel RA, Petrov A, Scapin G, Patel SB, Roy RS, Wu JK, Wyvratt MJ, Zhang BB, Zhu L, Thornberry NA, Weber AE. (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin -7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. J Med Chem. 2005 Jan 13;48(1):141-51. PMID:15634008 doi:10.1021/jm0493156