Talin
From Proteopedia
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[[Image:2x0c.png|left|200px|thumb|Crystal Structure of Talin [[2x0c]]]] | [[Image:2x0c.png|left|200px|thumb|Crystal Structure of Talin [[2x0c]]]] | ||
| - | {{STRUCTURE_2x0c| PDB=2x0c | SIZE= | + | {{STRUCTURE_2x0c| PDB=2x0c | SIZE=400| SCENE=Talin/Cv/1 |right|CAPTION=Talin [[2x0c]] }} |
[[Talin]] is involved in cell-cell contacts. It links integrins to actin. It contains a C-terminal rod domain with integrin binding sites (IBS) and actin binding sites (ABS) and N-terminal FERM domain with subdomains F0-F3. The F3 subdomains interacts with integrin. Talin contains 3 [[Vinculin]] binding sites VBS1-VBS3. The images at the left and at the right correspond to one representative Talin, ''i.e.'' the crystal structure of mouse Talin rod ([[2x0c]]). | [[Talin]] is involved in cell-cell contacts. It links integrins to actin. It contains a C-terminal rod domain with integrin binding sites (IBS) and actin binding sites (ABS) and N-terminal FERM domain with subdomains F0-F3. The F3 subdomains interacts with integrin. Talin contains 3 [[Vinculin]] binding sites VBS1-VBS3. The images at the left and at the right correspond to one representative Talin, ''i.e.'' the crystal structure of mouse Talin rod ([[2x0c]]). | ||
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== 3D Structures of Talin == | == 3D Structures of Talin == | ||
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| + | ''Updated December 2011'' | ||
=== Talin subdomains === | === Talin subdomains === | ||
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[[1mix]] – cTal F2F3<br /> | [[1mix]] – cTal F2F3<br /> | ||
[[2kgx]] – mTal F3+mTal fragment – NMR<br /> | [[2kgx]] – mTal F3+mTal fragment – NMR<br /> | ||
| - | [[3ivf]] – mTal FERM domain | + | [[3ivf]] – mTal FERM domain<br /> |
| - | + | [[2l10]] – mTal C - NMR | |
| - | === | + | === Talin integrin-binding sites === |
[[2jsw]], [[2qdq]] – mTal IBS – NMR<br /> | [[2jsw]], [[2qdq]] – mTal IBS – NMR<br /> | ||
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[[3fyq]] – Tal rod IBS2 – ''Drosophila melanogaster'' | [[3fyq]] – Tal rod IBS2 – ''Drosophila melanogaster'' | ||
| - | === | + | === Talin vinculin-binding sites === |
[[2kvp]], [[2b0h]] – mTal VBS3 – NMR<br /> | [[2kvp]], [[2b0h]] – mTal VBS3 – NMR<br /> | ||
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| - | === PIP kinase binding sites === | + | === Talin PIP kinase binding sites === |
[[1y19]] - mTal F2F3+ PIP kinase C-terminal<br /> | [[1y19]] - mTal F2F3+ PIP kinase C-terminal<br /> | ||
Revision as of 09:32, 20 December 2011
Talin is involved in cell-cell contacts. It links integrins to actin. It contains a C-terminal rod domain with integrin binding sites (IBS) and actin binding sites (ABS) and N-terminal FERM domain with subdomains F0-F3. The F3 subdomains interacts with integrin. Talin contains 3 Vinculin binding sites VBS1-VBS3. The images at the left and at the right correspond to one representative Talin, i.e. the crystal structure of mouse Talin rod (2x0c).
Contents |
3D Structures of Talin
Updated December 2011
Talin subdomains
2x0c, 2kbb, 3dyj, 1sj7, 1sj8 – mTal rod – mouse
2kma – mTal F0F1 – NMR
2kc1 - mTal F0 – NMR
2kc2 - mTal F1 – NMR
2hrj - cTal F2 – NMR
1mix – cTal F2F3
2kgx – mTal F3+mTal fragment – NMR
3ivf – mTal FERM domain
2l10 – mTal C - NMR
Talin integrin-binding sites
2jsw, 2qdq – mTal IBS – NMR
3g9w – mTal F2F3+integrin tail
1miz, 1mk7, 1mk9 - hTal+integrin tail
2h7d, 2h7e - cTal FERM F3+integrlin fragment – NMR
3fyq – Tal rod IBS2 – Drosophila melanogaster
Talin vinculin-binding sites
2kvp, 2b0h – mTal VBS3 – NMR
1xwj, 1zvz, 1zw2, 1zw3 - cTal VBS3+ vinculin head – chicken
1u6h - cTal VBS2+ vinculin head
1t01 - cTal VBS1+ vinculin head
1syq - hTal VBS1+ vinculin head – human
1rkc - hTal VBS3+ vinculin head
1u89 - mTal VBS2 – NMR
Talin PIP kinase binding sites
1y19 - mTal F2F3+ PIP kinase C-terminal
2g35 - mTal F3+PIP kinase peptide – NMR
Layilin binding sites
2k00 - cTal F3+layilin fragment – NMR
