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1z6j

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[[Image:1z6j.png|left|200px]]
[[Image:1z6j.png|left|200px]]
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{{STRUCTURE_1z6j| PDB=1z6j | SCENE= }}
{{STRUCTURE_1z6j| PDB=1z6j | SCENE= }}
===Crystal Structure of a ternary complex of Factor VIIa/Tissue Factor/Pyrazinone Inhibitor===
===Crystal Structure of a ternary complex of Factor VIIa/Tissue Factor/Pyrazinone Inhibitor===
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{{ABSTRACT_PUBMED_15913999}}
{{ABSTRACT_PUBMED_15913999}}
==About this Structure==
==About this Structure==
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[[1z6j]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z6J OCA].
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[[1z6j]] is a 3 chain structure of [[Factor VIIa]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z6J OCA].
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==See Also==
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*[[Factor VIIa|Factor VIIa]]
==Reference==
==Reference==
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<ref group="xtra">PMID:15913999</ref><ref group="xtra">PMID:12824026</ref><ref group="xtra">PMID:12954057</ref><references group="xtra"/>
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<ref group="xtra">PMID:015913999</ref><ref group="xtra">PMID:012824026</ref><ref group="xtra">PMID:012954057</ref><references group="xtra"/>
[[Category: Coagulation factor VIIa]]
[[Category: Coagulation factor VIIa]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]

Revision as of 05:23, 26 July 2012

Image:1z6j.png

Template:STRUCTURE 1z6j

Contents

Crystal Structure of a ternary complex of Factor VIIa/Tissue Factor/Pyrazinone Inhibitor

Template:ABSTRACT PUBMED 15913999

About this Structure

1z6j is a 3 chain structure of Factor VIIa with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Schweitzer BA, Neumann WL, Rahman HK, Kusturin CL, Sample KR, Poda GI, Kurumbail RG, Stevens AM, Stegeman RA, Stallings WC, South MS. Structure-based design and synthesis of pyrazinones containing novel P1 'side pocket' moieties as inhibitors of TF/VIIa. Bioorg Med Chem Lett. 2005 Jun 15;15(12):3006-11. PMID:15913999 doi:10.1016/j.bmcl.2005.04.037
  • South MS, Case BL, Wood RS, Jones DE, Hayes MJ, Girard TJ, Lachance RM, Nicholson NS, Clare M, Stevens AM, Stegeman RA, Stallings WC, Kurumbail RG, Parlow JJ. Structure-based drug design of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2319-25. PMID:12824026
  • Parlow JJ, Dice TA, Lachance RM, Girard TJ, Stevens AM, Stegeman RA, Stallings WC, Kurumbail RG, South MS. Polymer-assisted solution-phase library synthesis and crystal structure of alpha-ketothiazoles as tissue factor VIIa inhibitors. J Med Chem. 2003 Sep 11;46(19):4043-9. PMID:12954057 doi:http://dx.doi.org/10.1021/jm030130t

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