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1u9a
From Proteopedia
(New page: 200px<br /> <applet load="1u9a" size="450" color="white" frame="true" align="right" spinBox="true" caption="1u9a, resolution 2.0Å" /> '''HUMAN UBIQUITIN-CONJ...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1U9A is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1U9A OCA]]. | + | 1U9A is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]]. Active as [[http://en.wikipedia.org/wiki/Ligase Ligase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19]]. Structure known Active Site: C93. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1U9A OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: ubiquitin-directed proteolysis]] | [[Category: ubiquitin-directed proteolysis]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 08:23:16 2007'' |
Revision as of 06:18, 30 October 2007
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HUMAN UBIQUITIN-CONJUGATING ENZYME UBC9
Overview
Murine/human ubiquitin-conjugating enzyme Ubc9 is a functional homolog of, Saccharomyces cerevisiae Ubc9 that is essential for the viability of yeast, cells with a specific role in the G2-M transition of the cell cycle. The, structure of recombinant mammalian Ubc9 has been determined from two, crystal forms at 2.0 A resolution. Like Arabidopsis thaliana Ubc1 and S., cerevisiae Ubc4, murine/human Ubc9 was crystallized as a monomer, suggesting that previously reported hetero- and homo-interactions among, Ubcs may be relatively weak or indirect. Compared with the known crystal, structures of Ubc1 and Ubc4, which regulate different cellular processes, Ubc9 has a 5-residue insertion that forms a very exposed tight, beta-hairpin and a 2-residue insertion that forms a bulge in a loop close, to ... [(full description)]
About this Structure
1U9A is a [Single protein] structure of sequence from [Mus musculus]. Active as [Ligase], with EC number [6.3.2.19]. Structure known Active Site: C93. Full crystallographic information is available from [OCA].
Reference
Crystal structure of murine/human Ubc9 provides insight into the variability of the ubiquitin-conjugating system., Tong H, Hateboer G, Perrakis A, Bernards R, Sixma TK, J Biol Chem. 1997 Aug 22;272(34):21381-7. PMID:9261152
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