3lk1

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[[Image:3lk1.jpg|left|200px]]
 
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{{STRUCTURE_3lk1| PDB=3lk1 | SCENE= }}
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===X-ray structure of bovine SC0322,Ca(2+)-S100B===
===X-ray structure of bovine SC0322,Ca(2+)-S100B===
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{{ABSTRACT_PUBMED_21132089}}
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==Function==
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[[http://www.uniprot.org/uniprot/S100B_BOVIN S100B_BOVIN]] Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization (By similarity).<ref>PMID:14661952</ref>
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{{ABSTRACT_PUBMED_21132089}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:21132089</ref><references group="xtra"/>
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<ref group="xtra">PMID:021132089</ref><references group="xtra"/><references/>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Charpentier, T H.]]
[[Category: Charpentier, T H.]]

Revision as of 20:32, 4 April 2013

Template:STRUCTURE 3lk1

Contents

X-ray structure of bovine SC0322,Ca(2+)-S100B

Template:ABSTRACT PUBMED 21132089

Function

[S100B_BOVIN] Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization (By similarity).[1]

About this Structure

3lk1 is a 1 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

  • Wilder PT, Charpentier TH, Liriano MA, Gianni K, Varney KM, Pozharski E, Coop A, Toth EA, Mackerell AD, Weber DJ. In vitro screening and structural characterization of inhibitors of the S100B-p53 interaction. Int J High Throughput Screen. 2010 Jul 7;2010(1):109-126. PMID:21132089 doi:10.2147/IJHTS.S8210
  1. ↑ Bhattacharya S, Large E, Heizmann CW, Hemmings B, Chazin WJ. Structure of the Ca2+/S100B/NDR kinase peptide complex: insights into S100 target specificity and activation of the kinase. Biochemistry. 2003 Dec 16;42(49):14416-26. PMID:14661952 doi:http://dx.doi.org/10.1021/bi035089a

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OCA

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