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3kzd

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[[Image:3kzd.png|left|200px]]
 
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{{STRUCTURE_3kzd| PDB=3kzd | SCENE= }}
{{STRUCTURE_3kzd| PDB=3kzd | SCENE= }}
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===Crystal Structure of Free T-cell Lymphoma Invasion and Metastasis-1 PDZ Domain===
===Crystal Structure of Free T-cell Lymphoma Invasion and Metastasis-1 PDZ Domain===
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{{ABSTRACT_PUBMED_20361982}}
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==Function==
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[[http://www.uniprot.org/uniprot/TIAM1_HUMAN TIAM1_HUMAN]] Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA.
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{{ABSTRACT_PUBMED_20361982}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:20361982</ref><references group="xtra"/>
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<ref group="xtra">PMID:020361982</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Fuentes, E J.]]
[[Category: Fuentes, E J.]]
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[[Category: Pdz]]
[[Category: Pdz]]
[[Category: Phosphoprotein]]
[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
 
[[Category: Signaling protein]]
[[Category: Signaling protein]]
[[Category: Tiam1]]
[[Category: Tiam1]]

Revision as of 20:10, 4 April 2013

Template:STRUCTURE 3kzd

Contents

Crystal Structure of Free T-cell Lymphoma Invasion and Metastasis-1 PDZ Domain

Template:ABSTRACT PUBMED 20361982

Function

[TIAM1_HUMAN] Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA.

About this Structure

3kzd is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Shepherd TR, Klaus SM, Liu X, Ramaswamy S, DeMali KA, Fuentes EJ. The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion. J Mol Biol. 2010 May 21;398(5):730-46. Epub 2010 Mar 31. PMID:20361982 doi:10.1016/j.jmb.2010.03.047

Proteopedia Page Contributors and Editors (what is this?)

OCA

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