3n84

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Revision as of 05:14, 12 January 2011

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Template:STRUCTURE 3n84

Crystal Structure of the Grb2 SH2 Domain in Complex with a 23-Membered Macrocyclic Ligand Having the Sequence pYVNVP

Template:ABSTRACT PUBMED 21116482

About this Structure

3n84 is a 12 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Delorbe JE, Clements JH, Whiddon BB, Martin SF. Thermodynamic and Structural Effects of Macrocyclization as a Constraining Method in Protein-Ligand Interactions. ACS Med Chem Lett. 2010 Nov 11;1(8):448-452. PMID:21116482 doi:10.1021/ml100142y