3nyn
From Proteopedia
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{{STRUCTURE_3nyn| PDB=3nyn | SCENE= }} | {{STRUCTURE_3nyn| PDB=3nyn | SCENE= }} | ||
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===Crystal Structure of G Protein-Coupled Receptor Kinase 6 in Complex with Sangivamycin=== | ===Crystal Structure of G Protein-Coupled Receptor Kinase 6 in Complex with Sangivamycin=== | ||
| + | {{ABSTRACT_PUBMED_20729810}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/GRK6_HUMAN GRK6_HUMAN]] Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).<ref>PMID:19801552</ref> <ref>PMID:20048153</ref> | |
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:020729810</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Singh, P.]] | [[Category: Singh, P.]] | ||
[[Category: Tesmer, J J.G.]] | [[Category: Tesmer, J J.G.]] | ||
| + | [[Category: G protein-coupled receptor kinase]] | ||
| + | [[Category: Grk]] | ||
| + | [[Category: Kinase]] | ||
| + | [[Category: Rgs homology domain]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 11:56, 24 April 2013
Contents |
Crystal Structure of G Protein-Coupled Receptor Kinase 6 in Complex with Sangivamycin
Template:ABSTRACT PUBMED 20729810
Function
[GRK6_HUMAN] Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).[1] [2]
About this Structure
3nyn is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Boguth CA, Singh P, Huang CC, Tesmer JJ. Molecular basis for activation of G protein-coupled receptor kinases. EMBO J. 2010 Aug 20. PMID:20729810 doi:10.1038/emboj.2010.206
- ↑ Chen M, Philipp M, Wang J, Premont RT, Garrison TR, Caron MG, Lefkowitz RJ, Chen W. G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway. J Biol Chem. 2009 Dec 11;284(50):35040-8. doi: 10.1074/jbc.M109.047456. Epub 2009, Oct 2. PMID:19801552 doi:10.1074/jbc.M109.047456
- ↑ Busillo JM, Armando S, Sengupta R, Meucci O, Bouvier M, Benovic JL. Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling. J Biol Chem. 2010 Mar 5;285(10):7805-17. doi: 10.1074/jbc.M109.091173. Epub 2010 , Jan 4. PMID:20048153 doi:10.1074/jbc.M109.091173
