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3nwt

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[[Image:3nwt.png|left|200px]]
 
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{{STRUCTURE_3nwt| PDB=3nwt | SCENE= }}
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===Crystal structure of the N-terminal domain of the yeast telomere-binding and telomerase regulatory protein Cdc13===
===Crystal structure of the N-terminal domain of the yeast telomere-binding and telomerase regulatory protein Cdc13===
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{{ABSTRACT_PUBMED_20837709}}
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==Function==
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[[http://www.uniprot.org/uniprot/CDC13_YEAST CDC13_YEAST]] Single-stranded telomeric DNA-binding protein that regulates telomere replication. Has a role in both positive and negative regulation. Promotes [TG(1-3)] strand lengthening via interaction with EST1. Promotes [C(1-3)A] strand re-synthesis by DNA polymerase alpha via interaction with POL1. Negatively regulates telomere elongation of the G strand via binding with STN1 thereby inhibiting telomerase activity.<ref>PMID:11230149</ref> <ref>PMID:11390652</ref> <ref>PMID:10898792</ref>
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{{ABSTRACT_PUBMED_20837709}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:20837709</ref><references group="xtra"/>
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<ref group="xtra">PMID:020837709</ref><references group="xtra"/><references/>
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Harper, S.]]
[[Category: Harper, S.]]
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[[Category: Smith, J S.]]
[[Category: Smith, J S.]]
[[Category: Speicher, D W.]]
[[Category: Speicher, D W.]]
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[[Category: Cell cycle]]
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[[Category: Oligonucleotide/oligosaccharide binding fold - ob fold]]
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[[Category: Single stranded telomeric dna binding]]

Revision as of 12:01, 24 April 2013

Template:STRUCTURE 3nwt

Contents

Crystal structure of the N-terminal domain of the yeast telomere-binding and telomerase regulatory protein Cdc13

Template:ABSTRACT PUBMED 20837709

Function

[CDC13_YEAST] Single-stranded telomeric DNA-binding protein that regulates telomere replication. Has a role in both positive and negative regulation. Promotes [TG(1-3)] strand lengthening via interaction with EST1. Promotes [C(1-3)A] strand re-synthesis by DNA polymerase alpha via interaction with POL1. Negatively regulates telomere elongation of the G strand via binding with STN1 thereby inhibiting telomerase activity.[1] [2] [3]

About this Structure

3nwt is a 1 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

  • Mitchell MT, Smith JS, Mason M, Harper S, Speicher DW, Johnson FB, Skordalakes E. Cdc13 N-terminal dimerization, DNA binding, and telomere length regulation. Mol Cell Biol. 2010 Nov;30(22):5325-34. Epub 2010 Sep 13. PMID:20837709 doi:10.1128/MCB.00515-10
  1. ↑ Chandra A, Hughes TR, Nugent CI, Lundblad V. Cdc13 both positively and negatively regulates telomere replication. Genes Dev. 2001 Feb 15;15(4):404-14. PMID:11230149 doi:10.1101/gad.861001
  2. ↑ Meier B, Driller L, Jaklin S, Feldmann HM. New function of CDC13 in positive telomere length regulation. Mol Cell Biol. 2001 Jul;21(13):4233-45. PMID:11390652 doi:10.1128/MCB.21.13.4233-4245.2001
  3. ↑ Qi H, Zakian VA. The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase alpha and the telomerase-associated est1 protein. Genes Dev. 2000 Jul 15;14(14):1777-88. PMID:10898792

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