3qd4

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'''Unreleased structure'''
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[[Image:3qd4.jpg|left|200px]]
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The entry 3qd4 is ON HOLD
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{{STRUCTURE_3qd4| PDB=3qd4 | SCENE= }}
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Authors: Medina, J.R., Becker, C.J., Blackledge, C.W., Duquenne, C., Feng, Y., Grant, S.W., Heerding, D., Li, W.H., Miller, W.H., Romeril, S.P., Scherzer, D., Shu, A., Bobko, M.A., Chadderton, A.R., Dumble, M., Gradiner, C.M., Gilbert, S., Liu, Q., Rabindran, S.K., Sudakin, V., Xiang, H., Brady, P.G., Campobasso, N., Ward, P., Axten, J.M.
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===Phosphoinositide-Dependent Kinase-1 (PDK1) kinase domain with 1,1-Dimethylethyl{(3R,5R)-1-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-5-methyl-3-piperidinyl}carbamate===
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Description: Phosphoinositide-Dependent Kinase-1 (PDK1) kinase domain with 1,1-Dimethylethyl{(3R,5R)-1-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-5-methyl-3-piperidinyl}carbamate
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{{ABSTRACT_PUBMED_21341675}}
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==About this Structure==
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[[3qd4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QD4 OCA].
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==Reference==
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<ref group="xtra">PMID:21341675</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Axten, J M.]]
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[[Category: Becker, C J.]]
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[[Category: Blackledge, C W.]]
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[[Category: Bobko, M A.]]
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[[Category: Brady, P G.]]
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[[Category: Campobasso, N.]]
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[[Category: Chadderton, A R.]]
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[[Category: Dumble, M.]]
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[[Category: Duquenne, C.]]
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[[Category: Feng, Y.]]
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[[Category: Gilbert, S.]]
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[[Category: Gradiner, C M.]]
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[[Category: Grant, S W.]]
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[[Category: Heerding, D.]]
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[[Category: Li, W H.]]
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[[Category: Liu, Q.]]
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[[Category: Medina, J R.]]
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[[Category: Miller, W H.]]
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[[Category: Rabindran, S K.]]
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[[Category: Romeril, S P.]]
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[[Category: Scherzer, D.]]
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[[Category: Shu, A.]]
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[[Category: Sudakin, V.]]
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[[Category: Ward, P.]]
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[[Category: Xiang, H.]]

Revision as of 06:25, 9 March 2011

Image:3qd4.jpg

Template:STRUCTURE 3qd4

Phosphoinositide-Dependent Kinase-1 (PDK1) kinase domain with 1,1-Dimethylethyl{(3R,5R)-1-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-5-methyl-3-piperidinyl}carbamate

Template:ABSTRACT PUBMED 21341675

About this Structure

3qd4 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Medina JR, Becker CJ, Blackledge CW, Duquenne C, Feng Y, Grant SW, Heerding D, Li WH, Miller WH, Romeril SP, Scherzer D, Shu A, Bobko MA, Chadderton AR, Dumble M, Gardiner CM, Gilbert S, Liu Q, Rabindran SK, Sudakin V, Xiang H, Brady PG, Campobasso N, Ward P, Axten JM. Structure-Based Design of Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 (PDK1) Inhibitors. J Med Chem. 2011 Feb 22. PMID:21341675 doi:10.1021/jm101527u

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OCA

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