A Disintegrin And Metalloproteinase
From Proteopedia
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== 3D Structures of A Disintegrin And Metalloproteinase == | == 3D Structures of A Disintegrin And Metalloproteinase == | ||
| + | ===ADAM5=== | ||
| + | [[3hy7]], [[3hyg]] – hADAM5 catalytic domain (mutant) - human<br /> | ||
===ADAM10=== | ===ADAM10=== | ||
[[2ao7]] – ADAM10 - bovine<br /> | [[2ao7]] – ADAM10 - bovine<br /> | ||
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| + | ===ADAM13=== | ||
| + | |||
| + | [[3ghm]], [[3ghn]] – hADAM13 DTCS domains (mutant)<br /> | ||
| + | |||
===ADAM17=== | ===ADAM17=== | ||
Revision as of 10:10, 20 March 2011
A Disintegrin And Metalloproteinase (ADAM) are peptidases which cleave off extracellular portions of transmembrane proteins. ADAM inhibitors are used in anti-cancer therapy. ADAM family members are numbered. ADAM10 cleaves ephrin. ADAM17 processes the tumor necrosis factor-α. ADAM33 is implicated in asthma. The images at the left and at the right correspond to one representative ADAM, i.e. the crystal structure of bovine A Disintegrin And Metalloproteinase 10 (2ao7).
Contents |
3D Structures of A Disintegrin And Metalloproteinase
ADAM5
3hy7, 3hyg – hADAM5 catalytic domain (mutant) - human
ADAM10
2ao7 – ADAM10 - bovine
ADAM13
3ghm, 3ghn – hADAM13 DTCS domains (mutant)
ADAM17
1zxc, 2a8h, 2ddf – hADAM17 catalytic domain + inhibitor – human
2fv5, 2fv9, 2i47, 3b92, 3cki, 3e8r, 3edz, 3ewj, 3g42, 3l0t, 3l0v, 3le9, 3lea, 3lgp - hADAM17 catalytic domain (mutant)+ inhibitor
ADAM33
1r54, 1r55 – hADAM33 catalytic domain
