TolB

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TolB has been shown to be essential for the function of the Tol system in ''Escherichia coli''<ref>PMID: 19696740</ref>.
TolB has been shown to be essential for the function of the Tol system in ''Escherichia coli''<ref>PMID: 19696740</ref>.
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{{STRUCTURE_1crz | PDB=1crz | SCENE= }}
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{{STRUCTURE_1c5k | PDB=1c5k | SCENE= }}
==Structure==
==Structure==

Revision as of 13:21, 30 January 2011

TolB has been shown to be essential for the function of the Tol system in Escherichia coli[1].

Template:STRUCTURE 1c5k

Contents

Structure

TolB is a 44-kDa periplasmic protein associated with the outer membrane. It has two domains: an N-terminal α/β domain and a C-terminal six-bladed β-propeller (to which Pal and Colicin E9 bind) [2].

When Pal binds to TolB, several loops and propeller β-strands move, resulting in the latch strand of the β-propeller to move away.

Function

Related Tol entries


References

  1. Bonsor DA, Hecht O, Vankemmelbeke M, Sharma A, Krachler AM, Housden NG, Lilly KJ, James R, Moore GR, Kleanthous C. Allosteric beta-propeller signalling in TolB and its manipulation by translocating colicins. EMBO J. 2009 Sep 16;28(18):2846-57. Epub 2009 Aug 20. PMID:19696740 doi:10.1038/emboj.2009.224
  2. Bonsor DA, Hecht O, Vankemmelbeke M, Sharma A, Krachler AM, Housden NG, Lilly KJ, James R, Moore GR, Kleanthous C. Allosteric beta-propeller signalling in TolB and its manipulation by translocating colicins. EMBO J. 2009 Sep 16;28(18):2846-57. Epub 2009 Aug 20. PMID:19696740 doi:10.1038/emboj.2009.224

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